Faculty and staff in toxicology at WMed are engaged in conducting toxicology laboratory and clinical research. This includes:
Swift Toxicology of Overdose-Related Mortalities (STORM)
The increased frequency of opioid overdoses and consequential opioid-related deaths underscores a need to rapidly identify individuals with suspected opioid exposure. The lengthy time typically required to identify and report opioid exposure poses an ongoing threat to public health and public safety. An opioid surveillance program that provides a rapid turnaround time of laboratory test results has the potential to affect real-time responses to the opioid crisis.
The Swift Toxicology of Overdose-Related Mortalities (STORM) project at WMed is an opioid surveillance project funded by the Michigan Department of Health and Human Services. The STORM project began in September 2017 and yields enhanced and rapid estimates of deaths associated with opioid use, as well as providing the identification of specific opioids present at the time of death. Postmortem blood specimens are submitted by medical examiner offices covering counties throughout Michigan, and are assayed via Liquid-Chromatography Tandem Mass Spectrometry to identify forty-nine (49) opioids and twenty-five (25) non-opioid substances. STORM results are reported to the State within 48-72 hours from receipt of specimens at WMed.
Publications
Webster S.E., Les S.M., Deleon N., Heck D.M., Tsuj N.L., Clemente M.J., Jones P., Holodick N.E. Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging Immunity and Ageing. 2025;22
Adamczyk J.L., Prahlow J.A., Grieger-Nimmo R., Kundu R., Jones P. Analysis of 132 submandibular salivary glands using the Randox Evidence Investigator and Randox DOA ULTRA WB array Journal of Analytical Toxicology. 2024;48:591-597.
Ojha R., Krug S., Jones P., Koestler B.J. Intact and mutated Shigella diguanylate cyclases increase c-di-GMP Journal of Biological Chemistry. 2024;300
Olson K.R., Clear K.J., Takata T., Gao Y., Ma Z., Pfaff E., Travlos A., Luu J., Wilson K., Joseph Z., Kyle I., Kasko S.M., Jones P., Fukuto J., Xian M., Wu G., Straub K.D. Reaction Mechanisms of H<inf>2</inf>S Oxidation by Naphthoquinones Antioxidants. 2024;13
Olson K.R., Takata T., Clear K.J., Gao Y., Ma Z., Pfaff E., Mouli K., Kent T.A., Jones P., Fukuto J., Wu G., Straub K.D. The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase Antioxidants. 2024;13
Prahlow J.A., Castor M., Jones P. Insulin-Related Suicides—3 Cases Academic Forensic Pathology. 2024;14:146-155.
Prahlow J.A., Jones P., Bailey K., Grande A., Obead A., Pink C., Douglas E., Shattuck B., Fisher-Hubbard A., Brown T., deJong J.L. SARS-CoV-2 (COVID-19) Experience at an Academic Medical Examiner’s Office Academic Forensic Pathology. 2024;14:87-107.
Vohra V., Stroh-Steiner G.K., Jones P. Qualitative and quantitative characteristics of xylazine-associated deaths detected using a post-mortem toxicology testing program Clinical Toxicology. 2023;61:1040-1046.
Morton E., Prahlow J.A., Ianni J., Jones P. Novel Evaluation of Submandibular Salivary Gland Tissue for Use as an Alternative Postmortem Toxicology Specimen American Journal of Forensic Medicine and Pathology. 2021;42:328-334.
Stevens C., Li T., Ton E., Zou J., Douglas E., Jones P. Longitudinal Opioid Surveillance Project Involving Toxicologic Analysis of Postmortem Specimens from 9 Counties in Michigan Suggests the Discovery of New High-Intensity Drug Trafficking Areas American Journal of Forensic Medicine and Pathology. 2021;42:216-224.
Ton E., Stevens C., Moorman P., Markey M., Hunter B., Bush R., Jones P. Thirteen Cases of Valeryl Fentanyl in Michigan: A Call for Expanding Opioid Testing American Journal of Forensic Medicine and Pathology. 2021;42:367-372.
Strzyzewski L., Key P., Jones P., Prahlow J.A. Loperamide abuse and its sequelae American Journal of Forensic Medicine and Pathology. 2020;41:207-210.
Stevens C., Ton E., Jones P., Shattuck B. A complicated case of bowel obstruction with sepsis and methamphetamine toxicity in a child with pica Forensic Science, Medicine, and Pathology. 2019;15:598-602.
Christenson R.H., Lessig M., Miles G., Luebcke S., Stillions C., Jones P. Evaluation of the Elecsys Syphilis Immunoassay for Detection of Syphilis in Populations at Risk of Disease in the US and Argentina Journal of Applied Laboratory Medicine. 2018;3:89-99.
Guillaud D.A., Jones P., Prahlow J.A. The effect of chronic renal failure on the benzoylecgonine blood level American Journal of Forensic Medicine and Pathology. 2015;36:84-87.
Jones P., Mutsvunguma R., Prahlow J. Accidental death via intravaginal absorption of methamphetamine Forensic Science, Medicine, and Pathology. 2014;10:234-238.
Dickerson E.M., Jones P., Wilkins D., Regnier J., Prahlow J.A. Complicated suicide versus autoeroticism? A case involving multiple drugs and a porta-potty American Journal of Forensic Medicine and Pathology. 2013;34:29-33.
Matuch-Hite T., Jones P., Moriarity J. Interference of oxaprozin with benzodiazepines via enzyme immunoassay technique Journal of Analytical Toxicology. 1995;19(2):130.