Professor, Department of Investigative Medicine
Biosketch
Dr. Momoko Yoshimoto, MD, Ph.D., obtained her medical degree from Mie University Faculty of Medicine in 1993, followed by a two-year residency in general Pediatrics and a three-year fellowship in Pediatric Hematology-Oncology at Kobe City Medical Center General Hospital. She gained further experience as an attending Pediatric Hematology-Oncologist at Mie University for one year. Then, She entered Kyoto University Graduate School of Medicine and earned her Ph.D. in 2003. In 2005, Dr. Yoshimoto joined Dr. Mervin Yoder's lab as a postdoctoral researcher at Indiana University School of Medicine. Her exceptional contributions led to her promotion to Research Assistant Professor in 2009. Notably, she secured an R56 grant in 2015 and an R01 grant the following year. In 2016, she was recruited as an Associate Professor at the Center for Stem Cell and Regenerative Medicine at McGovern Medical School, the University of Texas Health Science Center at Houston, where she established her laboratory. Dr. Yoshimoto's scientific career has been dedicated to investigating developmental hematopoiesis in mouse embryos, focusing on the emergence of hematopoietic stem/progenitor cells from hemogenic endothelial cells. Her contributions are reflected in 68 peer-reviewed publications, with 11 as the corresponding author. She has recently secured a new R01 grant and earned an exceptional impact score for her R21 grant. In education, Dr. Yoshimoto has served as co-director of the Immunology Program at MD Anderson and UTHealth Graduate School of Biomedical Sciences for the past two years. She has also directed the Fundamental Immunology course and co-directed the Principle of Stem Cell Biology course for the last four years. Additionally, she actively contributes to the academic development of Ph.D. students, serving on committees for three students. Dr. Yoshimoto is extensively involved in scientific community activities. She has been invited multiple times to serve on NIH study sections. Moreover, she participates in the peer-review process by reviewing 3-4 original articles per year submitted to high-impact journals such as Nature Communications, Advanced Science, and Developmental Cell, among others. Additionally, she contributes her expertise by reviewing abstracts for annual meetings of the International Society of Experimental Hematology (ISEH) and the American Society of Hematology (ASH). Dr. Yoshimoto holds membership in the Junior Faculty Committee at ISEH and the ASH Scientific Committee. She is also a founding member of the Immunology Consortium at the Gulf Coast Consortium (GCC) in Texas, where she has been an integral part of the steering committee for the annual GCC Immunology meetings for the past three years.
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Education and Training
- Postdoctoral Fellowship 2009, Indiana University
- PhD 2003, Developmental Hematology, School of Medicine, Kyoto University
- Fellowship 1998, Kobe City General Hospital
- Residency 1995, Kobe City General Hospital
- MD 1993, School of Medicine, Mie University
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Research
- Pluripotent Stem Cells
- Lymphoid progenitors in the mouse embryo
- Hematopoietic Stem Cells
- Developmental Hematology
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Publications
Lin Y., Gil C.H., Banno K., Yokoyama M., Wingo M., Go E., Prasain N., Liu Y., Hato T., Naito H., Wakabayashi T., Sominskaia M., Gao M., Chen K., Geng F., Gomez Salinero J.M., Chen S., Shelley W.C., Yoshimoto M., Li Calzi S., Murphy M.P., Horie K., Grant M.B., Schreiner R., Redmond D., Basile D.P., Rafii S., Yoder M.C. ABCG2-Expressing Clonal Repopulating Endothelial Cells Serve to Form and Maintain Blood Vessels Circulation. 2024;150:451-465.
Syed A., Kobayashi M., Yoshimoto M. Protocol to induce cell labeling in vivo and to trace labeled hematopoietic cells using mouse models STAR Protocols. 2024;5
Abe J.I., Imanishi M., Li S., Zhang A., Ko K.A., Samanthapudi V.S.K., Lee L.L., Bojorges A.P., Gi Y.J., Hobbs B.P., Deswal A., Herrmann J., Lin S.H., Chini E.N., Shen Y.H., Schadler K.L., Nguyen T.H.M., Gupte A.A., Reyes-Gibby C., Yeung S.C.J., Abe R.J., Olmsted-Davis E.A., Krishnan S., Dantzer R., Palaskas N.L., Cooke J.P., Pownall H.J., Yoshimoto M., Fujiwara K., Hamilton D.J., Burks J.K., Wang G., Le N.T., Kotla S. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis Circulation Research. 2023;133:25-44.
Jain A., Casanova D., Padilla A.V., Paniagua Bojorges A., Kotla S., Ko K.A., Samanthapudi V.S.K., Chau K., Nguyen M.T.H., Wen J., Hernandez Gonzalez S.L., Rodgers S.P., Olmsted-Davis E.A., Hamilton D.J., Reyes-Gibby C., Yeung S.C.J., Cooke J.P., Herrmann J., Chini E.N., Xu X., Yusuf S.W., Yoshimoto M., Lorenzi P.L., Hobbs B., Krishnan S., Koutroumpakis E., Palaskas N.L., Wang G., Deswal A., Lin S.H., Abe J.I., Le N.T. Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights Frontiers in Cardiovascular Medicine. 2023;10
Kobayashi M., Wei H., Yamanashi T., Azevedo Portilho N., Cornelius S., Valiente N., Nishida C., Cheng H., Latorre A., Zheng W.J., Kang J., Seita J., Shih D.J., Wu J.Q., Yoshimoto M. HSC-independent definitive hematopoiesis persists into adult life Cell Reports. 2023;42(3)
Kobayashi M., Yoshimoto M. Multiple waves of fetal-derived immune cells constitute adult immune system Immunological Reviews. 2023;315(1):11-30.
Lin Y., Banno K., Gil C.H., Myslinski J., Hato T., Shelley W.C., Gao H., Xuei X., Liu Y., Basile D.P., Yoshimoto M., Prasain N., Tarnawsky S.P., Adams R.H., Naruse K., Yoshida J., Murphy M.P., Horie K., Yoder M.C. Origin, prospective identification, and function of circulating endothelial colony-forming cells in mice and humans JCI Insight. 2023;8(5)
Banerjee P., Olmsted-Davis E.A., Deswal A., Nguyen M.T., Koutroumpakis E., Palaskas N.L., Lin S.H., Kotla S., Reyes-Gibby C., Yeung S.C.J., Yusuf S.W., Yoshimoto M., Kobayashi M., Yu B., Schadler K., Herrmann J., Cooke J.P., Jain A., Chini E., Le N.T., Abe J.I. Cancer treatment-induced NAD<sup>+</sup> depletion in premature senescence and late cardiovascular complications Journal of Cardiovascular Aging. 2022;2
Imanishi M., Cheng H., Kotla S., Deswal A., Le N.T., Chini E., Ko K.A., Samanthapudi V.S.K., Lee L.L., Herrmann J., Xu X., Reyes-Gibby C., Yeung S.C.J., Schadler K.L., Yusuf S.W., Liao Z., Nurieva R., Amir E.a.D., Burks J.K., Palaskas N.L., Cooke J.P., Lin S.H., Kobayashi M., Yoshimoto M., Abe J.I. Radiation therapy induces immunosenescence mediated by p90RSK Frontiers in Cardiovascular Medicine. 2022;9
Yoshimoto M., Kosters A., Cornelius S., Valiente N., Cheng H., Latorre A., Nishida C., Ghosn E.E.B., Kobayashi M. Mast Cell Repopulating Ability Is Lost During the Transition From Pre-HSC to FL HSC Frontiers in Immunology. 2022;13
Ding J., Cardoso A.A., Yoshimoto M., Kobayashi M. The Earliest T-Precursors in the Mouse Embryo Are Susceptible to Leukemic Transformation Frontiers in Cell and Developmental Biology. 2021;9
Lewis K., Yoshimoto M., Takebe T. Fetal liver hematopoiesis: from development to delivery Stem Cell Research and Therapy. 2021;12(1)
Portilho N.A., Scarfo R., Bertesago E., Ismailoglu I., Kyba M., Kobayashi M., Ditadi A., Yoshimoto M. B1 lymphocytes develop independently of Notch signaling during mouse embryonic development Development (Cambridge). 2021;148(15)
Yoshimoto M., Ditadi A. The people behind the papers - Nathalia Azevedo Portilho, Rebecca Scarfò, Andrea Ditadi and Momoko Yoshimoto Development (Cambridge). 2021;148(15)
Kobayashi M., Lin Y., Mishra A., Shelly C., Gao R., Reeh C.W., Wang P.Z., Xi R., Liu Y., Wenzel P., Ghosn E., Liu Y., Yoshimoto M. Bmi1 maintains the self-renewal property of innate-like B lymphocytes Journal of Immunology. 2020;204(12):3262-3272.
Kobayashi M., Yoshimoto M. A Modified Semisolid Clonal Culture for Identification of B-1 and B-2 Progenitor Colony Forming Ability of Mouse Embryonic Hemogenic Endothelial Cells Bio-protocol. 2020;10(9)
Yoshimoto M. The ontogeny of murine B-1a cells International Journal of Hematology. 2020;111(5):622-627.
Azevedo Portilho N., Kobayashi M., Yoshimoto M. What do the lineage tracing studies tell us? Consideration for hematopoietic stem cell origin, dynamics, and leukemia-initiating cells International Journal of Hematology. 2019;109(1):35-40.
Ghosn E., Dorshkind K., Herzenberg L.A., Holodick N., Kantor A., Montecino-Rodriguez E., Rothstein T.L., Silverman G., Yang Y., Yoder M.C., Yoshimoto M. B1 B cell progenitors Science. 2019;364:248.
Ghosn E., Yoshimoto M., Nakauchi H., Weissman I.L., Herzenberg L.A. Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes Development (Cambridge). 2019;146(15)
Kobayashi M., Tarnawsky S.P., Wei H., Mishra A., Azevedo Portilho N., Wenzel P., Davis B., Wu J., Hadland B., Yoshimoto M. Hemogenic Endothelial Cells Can Transition to Hematopoietic Stem Cells through a B-1 Lymphocyte-Biased State during Maturation in the Mouse Embryo Stem Cell Reports. 2019;13(1):21-30.
Lin Y., Kobayashi M., Azevedo Portilho N., Mishra A., Gao H., Liu Y., Wenzel P., Davis B., Yoder M.C., Yoshimoto M. Long-Term Engraftment of ESC-Derived B-1 Progenitor Cells Supports HSC-Independent Lymphopoiesis Stem Cell Reports. 2019;12(3):572-583.
Yoshimoto M. B-1 progenitor acute lymphoid leukemia Blood. 2019;133(24):2557-2558.
Zaffiri L., Shah R.J., Stearman R.S., Rothhaar K., Emtiazjoo A.M., Yoshimoto M., Fisher A.J., Mickler E.A., Gartenhaus M.D., Cohort L.T.O.G., Diamond J.M., Geraci M.W., Christie J.D., Wilkes D.S. Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation Transplant Immunology. 2019;56
Hadland B., Yoshimoto M. Many layers of embryonic hematopoiesis: new insights into B-cell ontogeny and the origin of hematopoietic stem cells Experimental Hematology. 2018;60:1-9.
Hato T., Zollman A., Plotkin Z., El-Achkar T.M., Maier B.F., Louise Pay S., Dube S., Cabral P., Yoshimoto M., McClintick J., Dagher P.C. Endotoxin preconditioning reprograms S1 tubules and macrophages to protect the kidney Journal of the American Society of Nephrology. 2018;29(1):104-117.
Spidale N.A., Sylvia K., Narayan K., Miu B., Frascoli M., Melichar H.J., Zhihao W., Kisielow J., Palin A., Serwold T., Love P., Kobayashi M., Yoshimoto M., Jain N., Kang J. Interleukin-17-Producing γδ T Cells Originate from SOX13<sup>+</sup> Progenitors that Are Independent of γδTCR Signaling Immunity. 2018;49(5):857-872.e5.
Hadland B.K., Varnum-Finney B., Mandal P.K., Rossi D.J., Poulos M.G., Butler J.M., Rafii S., Yoder M.C., Yoshimoto M., Bernstein I.D. A Common Origin for B-1a and B-2 Lymphocytes in Clonal Pre- Hematopoietic Stem Cells Stem Cell Reports. 2017;8(6):1563-1572.
Kobayashi M., Nabinger S.c., Bai Y., Yoshimoto M., Gao R., Chen S., Yao C., Dong Y., Zhang L., Rodriguez S., Yashiro-Ohtani Y., Pear W.S., Carlesso N., Yoder M.C., Kapur R., Kaplan M.H., Daniel Lacorazza H., Zhang Z.Y., Liu Y. Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors Stem Cells. 2017;35(4):1053-1064.
Tarnawsky S.P., Yoshimoto M., Deng L., Chan R.J., Yoder M.C. Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice Developmental Dynamics. 2017;246(12):1001-1014.
Yoshimoto M., Yoder M.C. Developmental Biology of Stem Cells Fetal and Neonatal Physiology, 2-Volume Set. 2017:1094-1104.e2.
Yoon J., Wang H., Kim Y.C., Yoshimoto M., Abbasi S., Morse H.C. Plasma cell alloantigen ENPP1 is expressed by a subset of human B cells with potential regulatory functions Immunology and Cell Biology. 2016;94(8):719-728.
Hato T., Winfree S., Kalakeche R., Dube S., Kumar R., Yoshimoto M., Plotkin Z., Dagher P.C. The macrophage mediates the renoprotective effects of endotoxin preconditioning Journal of the American Society of Nephrology. 2015;26(6):1347-1362.
Kim H., Prasain N., Vemula S., Ferkowicz M.J., Yoshimoto M., Voytik-Harbin S.L., Yoder M.C. Human platelet lysate improves human cord blood derived ECFC survival and vasculogenesis in three dimensional (3D) collagen matrices Microvascular Research. 2015;101:72-81.
Yoshimoto M. The first wave of B lymphopoiesis develops independently of stem cells in the murine embryo Annals of the New York Academy of Sciences. 2015;1362(1):16-22.
Yoshimoto M., Koenig J.M. Stem Cells: Potential Therapy for Neonatal Injury? Clinics in Perinatology. 2015;42(3):597-612.
Adkins B., Yoshimoto M. Epigenetic regulation of the Th2 locus in fetal and neonatal T cells Advances in Neuroimmune Biology. 2014;5(2):69-73.
Arora N., Wenzel P., McKinney-Freeman S., Ross S., Kim P., Chou S., Yoshimoto M., Yoder M., Daley G. Effect of developmental stage of HSC and recipient on transplant outcomes Developmental Cell. 2014;29(5):621-628.
Kobayashi M., Shelley W.C., Seo W., Vemula S., Lin Y., Liu Y., Kapur R., Taniuchi I., Yoshimoto M. Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development Proceedings of the National Academy of Sciences of the United States of America. 2014;111(33):12151-12156.
Lin Y., Yoder M., Yoshimoto M. Lymphoid progenitor emergence in the murine embryo and yolk sac precedes stem cell detection Stem Cells and Development. 2014;23(11):1168-1177.
Prasain N., Lee M.R., Vemula S., Meador J.L., Yoshimoto M., Ferkowicz M.J., Fett A., Gupta M., Rapp B.M., Saadatzadeh M.R., Ginsberg M., Elemento O., Lee Y., Voytik-Harbin S.L., Chung H.M., Hong K.S., Reid E., O'Neill C.L., Medina R.J., Stitt A.W., Murphy M.P., Rafii S., Broxmeyer H.E., Yoder M.C. Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells Nature Biotechnology. 2014;32(11):1151-1157.
Chen H., Zhang W., Sun X., Yoshimoto M., Chen Z., Zhu W., Liu J., Shen Y., Yong W., Li D., Zhang J., Lin Y., Li B., VanDusen N.J., Snider P., Schwartz R.J., Conway S.J., Field L.J., Yoder M.C., Firulli A.B., Carlesso N., Towbin J.A., Shou W. Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity Development (Cambridge). 2013;140(9):1946-1957.
Sutton T.A., Hato T., Mai E., Yoshimoto M., Kuehl S., Anderson M., Mang H., Plotkin Z., Chan R.J., Dagher P.C. p53 is renoprotective after ischemic kidney injury by reducing inflammation Journal of the American Society of Nephrology. 2013;24(1):113-124.
Swiers G., Baumann C., O'Rourke J., Giannoulatou E., Taylor S., Joshi A., Moignard V., Pina C., Bee T., Kokkaliaris K.D., Yoshimoto M., Yoder M.C., Frampton J., Schroeder T., Enver T., Göttgens B., De Bruijn M.F.T.R. Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level Nature Communications. 2013;4
Yoshimoto M., Yoder M., Guevara P., Adkins B. The Murine Th2 Locus Undergoes Epigenetic Modification in the Thymus during Fetal and Postnatal Ontogeny PLoS ONE. 2013;8(1)
Choi E., Kraus M.R.C., Lemaire L.A., Yoshimoto M., Vemula S., Potter L.A., Manduchi E., Stoeckert C.J., Grapin-Botton A., Magnuson M.A. Dual lineage-specific expression of Sox17 during mouse embryogenesis Stem Cells. 2012;30(10):2297-2308.
Yoshimoto M., Porayette P., Glosson N.L., Conway S.J., Carlesso N., Cardoso A.A., Kaplan M.H., Yoder M.C. Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence Blood. 2012;119(24):5706-5714.
Yoshimoto M., Montecino-Rodriguez E., Ferkowicz M., Porayette P., Shelley W., Conway S., Dorshkind K., Yoder M. Embryonic day 9 yolk sac and intra-embryonic hemogenic endothelium independently generate a B-1 and marginal zone progenitor lacking B-2 potential Proceedings of the National Academy of Sciences of the United States of America. 2011;108(4):1468-1473.
Adamo L., Naveiras O., Wenzel P.L., McKinney-Freeman S., Mack P.J., Gracia-Sancho J., Suchy-Dicey A., Yoshimoto M., Lensch M.W., Yoder M.C., Garcia-Cardeña G., Daley G.Q. Biomechanical forces promote embryonic haematopoiesis Nature. 2009;459(7250):1131-1135.
Chang H., Yoshimoto M., Umeda K., Iwasa T., Mizuno Y., Fukada S.I., Yamamoto H., Motohashi N., Yuko-Miyagoe-Suzuki , Takeda S., Heike T., Nakahata T. Generation of transplantable, functional satellite-like cells from mouse embryonic stem cells FASEB Journal. 2009;23(6):1907-1919.
Pierre M., Yoshimoto M., Huang L., Richardson M., Yoder M. VEGF and IHH rescue definitive hematopoiesis in Gata-4 and Gata-6-deficient murine embryoid bodies Experimental Hematology. 2009;37(9):1038-1053.
Yoshimoto M., Heike T., Chang H., Kanatsu-Shinohara M., Baba S., Varnau J.T., Shinohara T., Yoder M.C., Nakahata T. Bone marrow engraftment but limited expansion of hematopoietic cells from multipotent germline stem cells derived from neonatal mouse testis Experimental Hematology. 2009;37(12):1400-1410.
Yoshimoto M., Yoder M. Developmental biology: Birth of the blood cell Nature. 2009;457(7231):801-803.
Lux C.T., Yoshimoto M., McGrath K., Conway S.J., Palis J., Yoder M.C. All primitive and definitive hematopoietic progenitor cells emerging before E10 in the mouse embryo are products of the yolk sac Blood. 2008;111(7):3435-3438.
Nakajima H., Sakakibara Y., Tambara K., Marui A., Yoshimoto M., Premaratne G.U., Lin X., Kanemitsu N., Sakaguchi G., Ikeda T., Nishimura K., Nakahata T., Komeda M. Delivery route in bone marrow cell transplantation should be optimized according to the etiology of heart disease Circulation Journal. 2008;72(9):1528-1535.
Okano T., Nakagawa T., Kita T., Kada S., Yoshimoto M., Nakahata T., Ito J. Bone marrow-derived cells expressing Iba1 are constitutively present as resident tissue macrophages in the mouse cochlea Journal of Neuroscience Research. 2008;86(8):1758-1767.
Tsuji S., Yoshimoto M., Takahashi K., Noda Y., Nakahata T., Heike T. Side population cells contribute to the genesis of human endometrium Fertility and Sterility. 2008;90(4 SUPPL.):1528-1537.
Yoshimoto M., Porayette P., Yoder M. Overcoming Obstacles in the Search for the Site of Hematopoietic Stem Cell Emergence Cell Stem Cell. 2008;3(6):583-586.
Baba S., Heike T., Umeda K., Iwasa T., Kaichi S., Hiraumi Y., Doi H., Yoshimoto M., Kanatsu-Shinohara M., Shinohara T., Nakahata T. Generation of cardiac and endothelial cells from neonatal mouse testis-derived multipotent germline stem cells Stem Cells. 2007;25(6):1375-1383.
Baba S., Heike T., Yoshimoto M., Umeda K., Doi H., Iwasa T., Lin X., Matsuoka S., Komeda M., Nakahata T. Flk1<sup>+</sup> cardiac stem/progenitor cells derived from embryonic stem cells improve cardiac function in a dilated cardiomyopathy mouse model Cardiovascular Research. 2007;76(1):119-131.
Fujino H., Hiramatsu H., Tsuchiya A., Niwa A., Noma H., Shiota M., Umeda K., Yoshimoto M., Ito M., Heike T., Nakahata T. Human cord blood CD34<sup>+</sup> cells develop into hepatocytes in the livers of NOD/SCID/γ<inf>c</inf><sup>null</sup> mice through cell fusion FASEB Journal. 2007;21(13):3499-3510.
Kato K., Yoshimoto M., Kato K., Adachi S., Yamayoshi A., Arima T., Asanoma K., Kyo S., Nakahata T., Wake N. Characterization of side-population cells in human normal endometrium Human Reproduction. 2007;22(5):1214-1223.
Shiota M., Heike T., Haruyama M., Baba S., Tsuchiya A., Fujino H., Kobayashi H., Kato T., Umeda K., Yoshimoto M., Nakahata T. Isolation and characterization of bone marrow-derived mesenchymal progenitor cells with myogenic and neuronal properties Experimental Cell Research. 2007;313(5):1008-1023.
Kato T., Heike T., Okawa K., Haruyama M., Shiraishi K., Yoshimoto M., Nagato M., Shibata M., Kumada T., Yamanaka Y., Hattori H., Nakahata T. A neurosphere-derived factor, cystatin C, supports differentiation of ES cells into neural stem cells Proceedings of the National Academy of Sciences of the United States of America. 2006;103(15):6019-6024.
Umeda K., Heike T., Yoshimoto M., Shinoda G., Shiota M., Suemori H., Hong Y.L., Chui D.H.K., Torii R., Shibuya M., Nakatsuji N., Nakahata T. Identification and characterization of hemoangiogenic progenitors during cynomolgus monkey embryonic stem cell differentiation Stem Cells. 2006;24(5):1348-1358.
Iida M., Heike T., Yoshimoto M., Baba S., Doi H., Nakahata T. Identification of cardiac stem cells with FLK1, CD31, and VE-cadherin expression during embryonic stem cell differentiation FASEB Journal. 2005;19(3):371-378.
Nagato M., Heike T., Kato T., Yamanaka Y., Yoshimoto M., Shimazaki T., Okano H., Nakahata T. Prospective characterization of neural stem cells by flow cytometry analysis using a combination of surface markers Journal of Neuroscience Research. 2005;80(4):456-466.
Saito M., Fujisawa A., Nishikomori R., Kambe N., Nakata-Hizume M., Yoshimoto M., Ohmori K., Okafuji I., Yoshioka T., Kusunoki T., Miyachi Y., Heike T., Nakahata T. Somatic mosaicism of CIAS1 in a patient with chronic infantile neurologic, cutaneous, articular syndrome Arthritis and Rheumatism. 2005;52(11):3579-3585.
Tsuchiya A., Heike T., Fujino H., Shiota M., Umeda K., Yoshimoto M., Matsuda Y., Ichida T., Aoyagi Y., Nakahata T. Long-term extensive expansion of mouse hepatic stem/progenitor cells in a novel serum-free culture system Gastroenterology. 2005;128(7):2089-2104.
Yoshimoto M., Chang H., Shiota M., Kobayashi H., Umeda K., Kawakami A., Heike T., Nakahata T. Two different roles of purified CD45<sup>+</sup>c-Kit<sup>+</sup>Sca-1 <sup>+</sup>Lin<sup>-</sup> cells after transplantation in muscles Stem Cells. 2005;23(5):610-618.
Kanatsu-Shinohara M., Inoue K., Lee J., Yoshimoto M., Ogonuki N., Miki H., Baba S., Kato T., Kazuki Y., Toyokuni S., Toyoshima M., Niwa O., Oshimura M., Heike T., Nakahata T., Ishino F., Ogura A., Shinohara T. Generation of pluripotent stem cells from neonatal mouse testis Cell. 2004;119(7):1001-1012.
Umeda K., Heike T., Yoshimoto M., Shiota M., Suemori H., Luo H.Y., Chui D.H.K., Torii R., Shibuya M., Nakatsuji N., Nakahata T. Development of primitive and definitive hematopoiesis from non-human primate embryonic stem cells in vitro Development. 2004;131(8):1869-1879.
Xu Y., Arai H., Zhuge X., Sano H., Murayama T., Yoshimoto M., Heike T., Nakahata T., Nishikawa S.I., Kita T., Yokode M. Role of Bone Marrow-Derived Progenitor Cells in Cuff-Induced Vascular Injury in Mice Arteriosclerosis, Thrombosis, and Vascular Biology. 2004;24(3):477-482.
Yoshimoto M., Shinohara T., Heike T., Shiota M., Kanatsu-Shinohara M., Nakahata T. Direct visualization of transplanted hematopoietic cellreconstitution in intact mouse organs indicates the presence of a niche Experimental Hematology. 2003;31(8):733-740.
Han H., Tanigaki K., Yamamoto N., Kuroda K., Yoshimoto M., Nakahata T., Ikuta K., Honjo T. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision International Immunology. 2002;14(6):637-645.
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Presentations
- Young B-1 cell prevent artherosclerosis. Yoshimoto M, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024