Gerrit J Bouma, PhD

Grellinger K.T., Phan H., Sheakley M., Bouma G.J., Bayer A., Shah B.A. BINGO! Elevating Medical Physiology Tutorials Through Gamification MedEdPORTAL : the journal of teaching and learning resources. 2025;21:11491.

Parsons A.M., Byrne S., Kooistra J., Dewey J., Zebolsky A.L., Alvarado G., Bouma G.J., Vanden Heuvel G.B., Larson E.D. G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD Nature Communications. 2025;16

Hollinshead F.K., Hanlon D.W., Hou W., Tasma Z., Damani T., Bouma G.J., Murtazina D.A., Chamley L. Use of equine embryo -derived mesenchymal stromal cells and their extracellular vesicles as a treatment for persistent breeding-induced endometritis in susceptible mares Journal of Equine Veterinary Science. 2024;139

Omar A.K., Li Puma L.C., Whitcomb L.A., Risk B.D., Witt A.C., Bruemmer J.E., Winger Q.A., Bouma G.J., Chicco A.J. High-fat diet during pregnancy promotes fetal skeletal muscle fatty acid oxidation and insulin resistance in an ovine model American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2023;325(5):R523-R533.

Parsons A.M., Rajendran R.R., Whitcomb L.A., Bouma G.J., Chicco A.J. Characterization of trophoblast mitochondrial function and responses to testosterone treatment in ACH-3P cells Placenta. 2023;137:70-77.

Watt M., Mohammadzadeh P., Pinsinski E., Hollinshead F.K., Bouma G.J. Corticotropin releasing hormone is present in the feline placenta and maternal serum Frontiers in Endocrinology. 2023;14

Ali A., Iqbal M.A., Abbas M.W., Bouma G.J., Anthony R.V., Spencer T.E., Winger Q.A. Trophectoderm Transcriptome Analysis in LIN28 Knockdown Ovine Conceptuses Suggests Diverse Roles of the LIN28-let-7 Axis in Placental and Fetal Development Cells. 2022;11(7)

Christensen A.O., Li G., Young C.H., Snow B., Khan S.A., Devore S.B., Edwards S., Bouma G.J., Navratil A.M., Cherrington B.D., Rothfuss H.M. Peptidylarginine deiminase enzymes and citrullinated proteins in female reproductive physiology and associated diseases Biology of Reproduction. 2022;107(6):1395-1410.

Thompson R.E., Bouma G.J., Hollinshead F.K. The Roles of Extracellular Vesicles and Organoid Models in Female Reproductive Physiology International Journal of Molecular Sciences. 2022;23(6)

Ali A., Hadlich F., Abbas M.W., Iqbal M.A., Tesfaye D., Bouma G.J., Winger Q.A., Ponsuksili S. Microrna–mrna networks in pregnancy complications: A comprehensive downstream analysis of potential biomarkers International Journal of Molecular Sciences. 2021;22(5):1-23.

Dailey D.D., Hess A.M., Bouma G.J., Duval D.L. MicroRNA Expression Changes and Integrated Pathways Associated With Poor Outcome in Canine Osteosarcoma Frontiers in Veterinary Science. 2021;8

Parsons A.M., Bouma G.J. A potential role and contribution of androgens in placental development and pregnancy Life. 2021;11(7)

Ali A., Bouma G.J., Anthony R.V., Winger Q.A. The role of LIN28-let-7-ARID3B pathway in placental development International Journal of Molecular Sciences. 2020;21(10)

Ali A., Stenglein M.D., Spencer T.E., Bouma G.J., Anthony R.V., Winger Q.A. Trophectoderm-specific knockdown of LIN28 decreases expression of genes necessary for cell proliferation and reduces elongation of sheep conceptus International Journal of Molecular Sciences. 2020;21(7)

Aubone A.M.P., Bisiau C.M., McCue P.M., Bouma G.J. Presence of Clock genes in equine full-term placenta Journal of Animal Science. 2020;98(4)

Evans R., Engelhorn H.J., Winger Q.A., Chicco A.J., Bouma G.J. A multiplex PCR genotyping assay to distinguish XX and XY tissues in sheep Molecular Biology Reports. 2020;47(9):7277-7282.

Hord T.K., Parsons Aubone A.M., Ali A., Templeton H.N., Evans R., Bruemmer J.E., Winger Q.A., Bouma G.J. Placenta specific gene targeting to study histone lysine demethylase and androgen signaling in ruminant placenta Animal Reproduction. 2020;17(3)

Twenter H., Klohonatz K., Davis K., Bass L., Coleman S.J., Bouma G.J., Bruemmer J.E. Transfer of MicroRNAs From Epididymal Epithelium to Equine Spermatozoa Journal of Equine Veterinary Science. 2020;87

van Campen H., Bishop J.V., Abrahams V.M., Bielefeldt‐Ohmann H., Mathiason C.K., Bouma G.J., Winger Q.A., Mayo C.E., Bowen R.A., Hansen T.R. Maternal Influenza A Virus Infection Restricts Fetal and Placental Growth and Adversely Affects the Fetal Thymic Transcriptome Viruses. 2020;12(9)

Ali A., Anthony R.V., Bouma G.J., Winger Q.A. LIN28-let-7 axis regulates genes in immortalized human trophoblast cells by targeting the ARID3B-complex FASEB Journal. 2019;33(11):12348-12363.

Klohonatz K.M., Coleman S.J., Cameron A.D., Hess A.M., Reed K.J., Canovas A., Medrano J.F., Islas-Trejo A.D., Kalbfleisch T., Bouma G.J., Bruemmer J.E. Non-coding RNA sequencing of equine endometrium during maternal recognition of pregnancy Genes. 2019;10(10)

Klohonatz K.M., Coleman S.J., Islas-Trejo A.D., Medrano J.F., Hess A.M., Kalbfleisch T., Thomas M.G., Bouma G.J., Bruemmer J.E. Coding RNA sequencing of equine endometrium during maternal recognition of pregnancy Genes. 2019;10(10)

Klohonatz K.M., Nulton L.C., Hess A.M., Bouma G.J., Bruemmer J.E. The role of embryo contact and focal adhesions during maternal recognition of pregnancy PLoS ONE. 2019;14(3)

McWhorter E.S., West R.C., Russ J.E., Ali A., Winger Q.A., Bouma G.J. LIN28B regulates androgen receptor in human trophoblast cells through Let-7c Molecular Reproduction and Development. 2019;86(9):1086-1093.

West R.C., McWhorter E.S., Ali A., Goetzman L.N., Russ J.E., Gonzalez-Berrios C.L., Anthony R.V., Bouma G.J., Winger Q.A. HMGA2 is regulated by LIN28 and BRCA1 in human placental cells Biology of Reproduction. 2019;100(1):227-238.

West R.C., Russ J.E., Bouma G.J., Winger Q.A. BRCA1 regulates HMGA2 levels in the Swan71 trophoblast cell line Molecular Reproduction and Development. 2019;86(11):1663-1670.

Da Silveira J., Andrade G.M., Perecin F., Meireles F.V., Winger Q.A., Bouma G.J. Isolation and analysis of exosomal MicroRNAs from ovarian follicular fluid Methods in Molecular Biology. 2018;1733:53-63.

Jeckel K.M., Boyarko A.C., Bouma G.J., Winger Q.A., Anthony R.V. Chorionic somatomammotropin impacts early fetal growth and placental gene expression Journal of Endocrinology. 2018;237(3):301-310.

Juliano C.d.S., de Ávila A.C.F.C.M., Garrett H.L., Bruemmer J.E., Winger Q.A., Bouma G.J. Cell-secreted vesicles containing microRNAs as regulators of gamete maturation Journal of Endocrinology. 2018;236(1):R15-R27.

McWhorter E.S., Russ J.E., Winger Q.A., Bouma G.J. Androgen and estrogen receptors in placental physiology and dysfunction Frontiers in Biology. 2018;13(5):315-326.

West R., Bouma G., Winger Q. Shifting perspectives from "oncogenic" to oncofetal proteins; How these factors drive placental development Reproductive Biology and Endocrinology. 2018;16(1)

Davis K., Klohonatz K., Bouma G., Bruemmer J. Androgen Receptor in the Term Equine Placenta Journal of Equine Veterinary Science. 2017;54:8-11.

Twenter H.M., Belk A.D., Klohonatz K.M., Bass L.D., Bouma G.J., Bruemmer J.E. An Investigation Into miRNAs in the Equine Epididymis as Potential Regulators of Spermatozoal Maturation Journal of Equine Veterinary Science. 2017;48:61-68.

Klohonatz K.M., Cameron A.D., Hergenreder J.R., da Silveira J.C., Belk A.D., Veeramachaneni D.N.R., Bouma G.J., Bruemmer J.E. Circulating miRNAs as potential alternative cell signaling associated with maternal recognition of pregnancy in the mare Biology of Reproduction. 2016;95(6):1-12.

Campos-Chillon F., Farmerie T.A., Bouma G.J., Clay C.M., Carnevale E.M. Effects of aging on gene expression and mitochondrial DNA in the equine oocyte and follicle cells Reproduction, Fertility and Development. 2015;27(6):925-933.

Cleys E.R., Halleran J.L., Enriquez V.A., Da Silveira J.C., West R.C., Winger Q.A., Anthony R.V., Bruemmer J.E., Clay C.M., Bouma G.J. Androgen receptor and histone lysine demethylases in ovine placenta e0117472 PLoS ONE. 2015;10(2)

Da Silveira J.C., Winger Q.A., Bouma G.J., Carnevale E.M. Effects of age on follicular fluid exosomal microRNAs and granulosa cell transforming growth factor-β signalling during follicle development in the mare Reproduction, Fertility and Development. 2015;27(6):897-905.

Enriquez V.A., Cleys E.R., Da Silveira J.C., Spillman M.A., Winger Q.A., Bouma G.J. High LIN28A expressing ovarian cancer cells secrete exosomes that induce invasion and migration in HEK293 cells BioMed Research International. 2015;2015

Hatzel J.N., Bouma G.J., Cleys E.R., Bemis L.T., Ehrhart E.J., McCue P.M. Identification of heat shock protein 10 within the equine embryo, endometrium, and maternal peripheral blood mononuclear cells Theriogenology. 2015;83(5):832-839.

Klohonatz K., Hess A., Hansen T., Squires E., Bouma G., Bruemmer J. Equine endometrial gene expression changes during and after maternal recognition of pregnancy Journal of Animal Science. 2015;93(7):3364-3376.

Cleys E.R., Halleran J.L., Mcwhorter E., Hergenreder J., Enriquez V.A., da Silveira J.C., Bruemmer J.E., Winger Q.A., Bouma G.J. Identification of microRNAs in exosomes isolated from serum and umbilical cord blood, as well as placentomes of gestational day 90 pregnant sheep Molecular Reproduction and Development. 2014;81(11):983-993.

Da Silveira J.C., Carnevale E.M., Winger Q.A., Bouma G.J. Regulation of ACVR1 and ID2 by cell-secreted exosomes during follicle maturation in the mare Reproductive Biology and Endocrinology. 2014;12(1)

Jeckel K.M., Bouma G.J., Hess A.M., Petrilli E.B., Frye M.A. Dietary fatty acids alter left ventricular myocardial gene expression in Wistar rats Nutrition Research. 2014;34(8):694-706.

Le C.H., Mulligan C.M., Routh M.A., Bouma G.J., Frye M.A., Jeckel K.M., Sparagna G.C., Lynch J.M., Moore R.L., McCune S.A., Bristow M., Zarini S., Murphy R.C., Chicco A.J. Delta-6-desaturase links polyunsaturated fatty acid metabolism with phospholipid remodeling and disease progression in heart failure Circulation: Heart Failure. 2014;7(1):172-183.

Knoll J.G., Clay C.M., Bouma G.J., Henion T.R., Schwarting G.A., Millar R.P., Tobet S.A. Developmental profile and sexually dimorphic expression of Kiss1 and Kiss1r in the fetal mouse brain Frontiers in Endocrinology. 2013;4

Seabrook J.L., Cantlon J.D., Cooney A.J., McWhorter E.E., Fromme B.A., Bouma G.J., Anthony R.V., Winger Q.A. Role of LIN28A in mouse and human trophoblast cell differentiation Biology of Reproduction. 2013;89(4)

Correa S., Washburn L., Kahlon R., Musson M., Bouma G., Eicher E., Albrecht K. Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway PLoS Genetics. 2012;8(4)

Jeckel K.M., Veeramachaneni D.N.R., Chicco A.J., Chapman P.L., Mulligan C.M., Hegarty J.R., Pagliassotti M.J., Ferguson L.A., Bouma G.J., Frye M.A. Docosahexaenoic Acid Supplementation Does Not Improve Western Diet-Induced Cardiomyopathy in Rats PLoS ONE. 2012;7(12)

Patterson A.L., Squires E.L., Hansen T.R., Bouma G.J., Bruemmer J.E. Gene profiling of inflammatory genes in day 18 endometria from pregnant and non-pregnant mares Molecular Reproduction and Development. 2012;79(11):777-784.

Zhang Q., Bouma G., McClellan K., Tobet S. Hypothalamic expression of snoRNA Snord116 is consistent with a link to the hyperphagia and obesity symptoms of Prader-Willi syndrome International Journal of Developmental Neuroscience. 2012;30(6):479-485.

da Silveira J.C., Veeramachaneni D.N.R., Winger Q.A., Carnevale E.M., Bouma G.J. Cell-secreted vesicles in equine ovarian follicular fluid contain mirnas and proteins: A possible new form of cell communication within the ovarian follicle Biology of Reproduction. 2012;86(3)

Torley K.J., da Silveira J.C., Smith P., Anthony R.V., Veeramachaneni D.R., Winger Q.A., Bouma G.J. Expression of miRNAs in ovine fetal gonads: Potential role in gonadal differentiation Reproductive Biology and Endocrinology. 2011;9

Ashley R.L., Henkes L.E., Bouma G.J., Pru J.K., Hansen T.R. Deletion of the Isg15 gene results in up-regulation of decidual cell survival genes and down-regulation of adhesion genes: Implication for regulation by IL-1 Endocrinology. 2010;151(9):4527-4536.

Bouma G., Hudson Q., Washburn L., Eicher E. New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and Sertoli cell differentiation. Biology of reproduction. 2010;82(2):380-389.

Bouma G.J., Hudston Q.J., Washburn L.I., Eicher E.M. New candidate genes identified for controlling mouse gonadal sex determination and the early stages of granulosa and sertoli cell differentiation Journal of Urology. 2010;184(4):1568-1569.

Bouma G., Affourtit J., Bult C., Eicher E. Transcriptional profile of mouse pre-granulosa and Sertoli cells isolated from early-differentiated fetal gonads Gene Expression Patterns. 2007;7(1-2):113-123.

Bouma G., Washburn L., Albrecht K., Eicher E. Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice Proceedings of the National Academy of Sciences of the United States of America. 2007;104(38):14994-14999.

Bouma G., Albrecht K., Washburn L., Recknagel A., Churchill G., Eicher E. Gonadal sex reversal in mutant Dax1 XY mice: A failure to upregulate Sox9 in pre-Sertoli cells Development. 2005;132(13):3045-3054.

Bouma G.J., Cloud J.G., Nagler J.J. An in vitro system for the long-term tissue culture of juvenile rainbow trout (Oncorhynchus mykiss) testis Journal of Experimental Zoology Part A: Comparative Experimental Biology. 2005;303(8):698-703.

Bouma G., Hart G., Washburn L., Recknagel A., Eicher E. Using real time RT-PCR analysis to determine multiple gene expression patterns during XX and XY mouse fetal gonad development Gene Expression Patterns. 2004;5(1):141-149.