Adjunct Community Assistant Professor, Department of Biomedical Sciences
Contact Information
Email:Biosketch
Jeremy Duncan, PhD, received his undergraduate degree at Luther College, Decorah, Iowa. He completed his PhD in biology at the University of Iowa, Iowa City, Iowa, and postdoctoral training in the Department of Otolaryngology at Johns Hopkins Medical School, Baltimore, Maryland, and subsequently the Department of Otolaryngology at the University of Utah, Salt Lake City, Utah. He then accepted a faculty position in the Department of Biological Sciences at Western Michigan University, Kalamazoo, Michigan. His research laboratory focuses on inner ear and brain development, and strategies to restore hearing. He is currently the primary investigator of an NIH grant focused on profiling the molecular development of the inner ear and strategies to restore the normal cellular architecture after hearing loss. In addition to teaching and research, Dr. Duncan has a particular interest in training the next generation of scientists by both mentoring students in his lab and leading outreach opportunities to engage elementary students in exploring biology.
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Education and Training
- Postdoctoral Research Fellowship 2017, Otolaryngology, School of Medicine, University of Utah
- Postdoctoral Research Fellowship 2013, Otolaryngology, School of Medicine, Johns Hopkins University
- PhD 2012, Biology, University of Iowa
- MS 2007, Clinical Anatomy, School of Medicine, Creighton University
- BA 2006, Biology and Psychology, Luther College
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Research
- Pediatric Hearing Loss
- Neurosciences
- Hearing Restoration
- Hearing Loss, Sensorineural
- Gene Expression Regulation, Developmental
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Publications
Blinkiewicz P.V., Long M.R., Stoner Z.A., Ketchum E.M., Sheltz-Kempf S.N., Duncan J.S. Gata3 is required in late proneurosensory development for proper sensory cell formation and organization Scientific Reports. 2023;13
Stoner Z.A., Ketchum E.M., Sheltz-Kempf S., Blinkiewicz P.V., Elliott K.L., Duncan J.S. Fzd3 Expression Within Inner Ear Afferent Neurons Is Necessary for Central Pathfinding Frontiers in Neuroscience. 2022;15
Duncan J.S., Cox B.C. 2.15 - Anatomy and Development of the Inner Ear The Senses: A Comprehensive Reference: Volume 1-7, Second Edition. 2020;2:253-276.
Ketchum E.M., Sheltz-Kempf S.N., Duncan J.S. 6.11 - Molecular Basis of Vestibular Organ Formation During Ontogeny The Senses: A Comprehensive Reference: Volume 1-7, Second Edition. 2020;6:129-144.
Duncan J.S., Fritzsch B., Houston D.W., Ketchum E.M., Kersigo J., Deans M.R., Elliott K.L. Topologically correct central projections of tetrapod inner ear afferents require Fzd3 Scientific Reports. 2019;9(1)
Fritzsch B., Elliott K.L., Pavlinkova G., Duncan J.S., Hansen M.R., Kersigo J.M. Neuronal migration generates new populations of neurons that develop unique connections, physiological properties and pathologies Frontiers in Cell and Developmental Biology. 2019;7(APR)
Elliott K., Fritzsch B., Duncan J. Evolutionary and developmental biology provide insights into the regeneration of organ of Corti hair cells Frontiers in Cellular Neuroscience. 2018;12
Duncan J., Stoller M., Francl A., Tissir F., Devenport D., Deans M. Celsr1 coordinates the planar polarity of vestibular hair cells during inner ear development Developmental Biology. 2017;423(2):126-137.
Fritzsch B., Duncan J.S., Kersigo J., Gray B., Elliott K.L. Neuroanatomical tracing techniques in the ear: History, state of the art, and future developments Methods in Molecular Biology. 2016;1427:243-262.
Saito Y., Miranda-Rottmann S., Ruggiu M., Park C.Y., Fak J.J., Zhong R., Duncan J.S., Fabella B.A., Junge H.J., Chen Z., Araya R., Fritzsch B., Hudspeth A.J., Darnell R.B. NOVA2-mediated RNA regulation is required for axonal pathfinding during development eLife. 2016;5(MAY2016)
Duncan J.S., Elliott K.L., Kersigo J., Gray B., Fritzsch B. Combining whole-mount in situ hybridization with neuronal tracing and immunohistochemistry In Situ Hybridization Methods. 2015:339-352.
Duncan J.S., Elliott K.L., Kersigo J., Gray B., Fritzsch B. Combining whole-mount in situ hybridization with neuronal tracing and immunohistochemistry Neuromethods. 2015;99:339-352.
Cheng L., Desai J., Miranda C.J., Duncan J.S., Qiu W., Nugent A.A., Kolpak A.L., Wu C.C., Drokhlyansky E., Delisle M.M., Chan W.M., Wei Y., Propst F., Samara L.R.P., Fritzsch B., Engle E.C. Human CFEOM1 mutations attenuate KIF21A autoinhibition and cause oculomotor axon stalling Neuron. 2014;82(2):334-349.
Fritzsch B., Kopecky B.J., Duncan J.S. Development of the Mammalian 'Vestibular' System: Evolution of Form to Detect Angular and Gravity Acceleration Development of Auditory and Vestibular Systems: Fourth Edition. 2014:339-367.
Copley C.O., Duncan J.S., Liu C., Cheng H., Deans M.R. Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2 Journal of Neuroscience. 2013;33(35):14001-14016.
Duncan J., Fritzsch B. Continued Expression of GATA3 Is Necessary for Cochlear Neurosensory Development PLoS ONE. 2013;8(4)
Fritzsch B., Pan N., Jahan I., Duncan J.S., Kopecky B.J., Elliott K.L., Kersigo J., Yang T. Evolution and development of the tetrapod auditory system: An organ of Corti-centric perspective Evolution and Development. 2013;15(1):63-79.
Duncan J., Fritzsch B. Transforming the vestibular system one molecule at a time: The molecular and developmental basis of vertebrate auditory evolution Advances in Experimental Medicine and Biology. 2012;739:173-186.
Duncan J.S., Fritzsch B. Evolution of sound and balance perception: Innovations that aggregate single hair cells into the ear and transform a gravistatic sensor into the organ of corti Anatomical Record. 2012;295(11):1760-1774.
Jahan I., Pan N., Kersigo J., Calisto L.E., Morris K.A., Kopecky B., Duncan J.S., Beisel K.W., Fritzsch B. Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival PLoS ONE. 2012;7(1)
Kopecky B.J., Duncan J.S., Elliott K.L., Fritzsch B. Three-dimensional reconstructions from optical sections of thick mouse inner ears using confocal microscopy Journal of Microscopy. 2012;248(3):292-298.
Pan N., Jahan I., Kersigo J., Duncan J.S., Kopecky B., Fritzsch B. A novel Atoh1 "self-terminating" mouse model reveals the necessity of proper Atoh1 level and duration for hair cell differentiation and viability PLoS ONE. 2012;7(1)
Duncan J., Kersigo J., Gray B., Fritzsch B. Combining lipophilic dye, in situ hybridization, immunohistochemistry, and histology Journal of Visualized Experiments. 2011(49)
Duncan J., Lim K., Engel J., Fritzsch B. Limited inner ear morphogenesis and neurosensory development are possible in the absence of GATA3 International Journal of Developmental Biology. 2011;55(3):297-303.
Fritzsch B., Jahan I., Pan N., Kersigo J., Duncan J., Kopecky B. Dissecting the molecular basis of organ of Corti development: Where are we now? Hearing Research. 2011;276(1-2):16-26.
Tonniges J., Hansen M., Duncan J., Bassett M.J., Fritzsch B., Gray B.D., Easwaran A., Nichols M.G. Photo- and bio-physical characterization of novel violet and near-infrared lipophilic fluorophores for neuronal tracing Journal of Microscopy. 2010;239(2):117-134.