Gregory B Vanden Heuvel, PhD

Parsons A.M., Byrne S., Kooistra J., Dewey J., Zebolsky A.L., Alvarado G., Bouma G.J., Vanden Heuvel G.B., Larson E.D. G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD Nature Communications. 2025;16

Griesmann H., Mühl S., Riedel J., Theuerkorn K., Sipos B., Esposito I., Heuvel G.B.V., Michl P. Cux1 enhances pancreatic cancer formation by synergizing with kras and inducing mek/erk‐dependent proliferation Cancers. 2021;13(10)

Srivastava T., Joshi T., Heruth D.P., Rezaiekhaligh M.H., Garola R.E., Zhou J., Boinpelly V.C., Ali M.F., Alon U.S., Sharma M., Vanden Heuvel G.B., Mahajan P., Priya L., Jiang Y., McCarthy E.T., Savin V.J., Sharma R. A mouse model of prenatal exposure to Interleukin-6 to study the developmental origin of health and disease Scientific Reports. 2021;11

Livingston S., Carlton C., Sharma M., Kearns D., Baybutt R., Vanden Heuvel G.B. Cux1 regulation of the cyclin kinase inhibitor p27 ^kip1 in polycystic kidney disease is attenuated by HDAC inhibitors Gene: X. 2019;2

Puri R.V., Yerrathota S., Home T., Idowu J.Y., Chakravarthi V.P., Ward C.J., Singhal P.C., Heuvel G.B.V., Fields T.A., Sharma M. Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy DMM Disease Models and Mechanisms. 2019;12

Porath B., Livingston S., Andres E.L., Petrie A.M., Wright J.C., Woo A.E., Carlton C.G., Baybutt R., Vanden Heuvel G.B. Cux1 promotes cell proliferation and polycystic kidney disease progression in an ADPKD mouse model American Journal of Physiology - Renal Physiology. 2017;313(4):F1050-F1059.

Keator C., Dickinson B.L., Lackey W.L., Morris A., Quesnelle K.M., Riddle D.R., Sheakley M.L., Vanden Heuvel G.B., Vandre D.D. Explorations: a New Approach to Self-Directed Learning in a Competency-Based Curriculum Medical Science Educator. 2016;26:777-785.

Paul B., Vanden Heuvel G. Kidney: Polycystic kidney disease Wiley Interdisciplinary Reviews: Developmental Biology. 2014;3(6):465-487.

Sharma M., Magenheimer L.K., Home T., Tamano K.N., Singhal P.C., Hyink D.P., Klotman P.E., Vanden Heuvel G.B., Fields T.A. Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy American Journal of Physiology - Renal Physiology. 2013;304(8):1127-1136.

Sharma N., Malarkey E.B., Berbari N.F., O'Connor A.K., Heuvel G.B.V., Mrug M., Yoder B.K. Proximal tubule proliferation is insufficient to induce rapid cyst formation after cilia disruption Journal of the American Society of Nephrology. 2013;24(3):456-464.

Kroll M., Viss E.S., Lamb J., Horstman J., Powell A., Van Wyk A., Hinkkala K., Hoogland T., Schippers M., Shannon S., Carlton C.G., Sharma M., Taylor A., Vanden Heuvel G.B., Jelsma T.N. Asynchronous expression of the homeodomain protein CUX1 in sertoli cells and spermatids during spermatogenesis in mice Biology of Reproduction. 2011;84(3):455-465.

Paul B.M., Vassmer D., Taylor A., Magenheimer L., Carlton C.G., Piontek K.B., Germino G.G., Vanden Heuvel G.B. Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts Developmental Dynamics. 2011;240(6):1493-1501.

Sharma M., Callen S., Zhang D., Singhal P.C., Vanden Heuvel G.B., Buch S. Activation of Notch signaling pathway in HIV-associated nephropathy AIDS. 2010;24(14):2161-2170.

Vanden Heuvel G.B. CD14: A candidate biomarker for the prognosis of polycystic kidney disease Kidney International. 2010;78(6):537-538.

Alcalay N.I., Vanden Heuvel G.B. Regulation of cell proliferation and differentiation in the kidney Frontiers in Bioscience. 2009;14(13):4978-4991.

Iulianella A., Sharma M., Vanden Hauvel G.B., Trainor P.A. Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord Development. 2009;136(14):2329-2334.

Sharma M., Brantley J.G., Vassmer D., Chaturvedi G., Baas J., Vanden Heuvel G.B. The homeodomain protein Cux1 interacts with Grg4 to repress p27^kip1 expression during kidney development Gene. 2009;439(1-2):87-94.

Alcalay N.I., Sharma M., Vassmer D., Chapman B., Paul B., Zhou J., Brantley J.G., Wallace D.P., Maser R.L., Vanden Heuvel G.B. Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1 American Journal of Physiology - Renal Physiology. 2008;295(6)

Iulianella A., Sharma M., Durnin M., Vanden Heuvel G.B., Trainor P.A. Cux2 (Cut12) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis Development. 2008;135(4):729-741.

Alcalay N.I., Brantley J.G., Sharma M., Gooch J.L., Vanden Heuvel G.B. Ectopic expression of the homeobox gene Cux-1 rescues calcineurin inhibition in mouse embryonic kidney cultures Developmental Dynamics. 2007;236(1):184-191.

Vanden Heuvel G.B., Payne J.A., Igarashi P., Forbush B. Expression of the basolateral Na-K-Cl cotransporter during mouse nephrogenesis and embryonic development Gene Expression Patterns. 2006;6(8):1000-1006.

Sharma M., Brantley J.G., Alcalay N.I., Zhou J., Heystek E., Maser R.L., Vanden Heuvel G.B. Differential expression of Cux-1 and p21 in polycystic kidneys from Pkd1 null and cpk mice Kidney International. 2005;67(2):432-442.

Vanden Heuvel G.B., Brantley J.G., Alcalay N.I., Sharma M., Kemeny G., Warolin J., Ledford A., Pinson D.M. Hepatomegaly in transgenic mice expressing the homeobox gene Cux-1 Molecular Carcinogenesis. 2005;43(1):18-30.

Sharma M., Fopma A., Brantley J.G., Vanden Heuvel G.B. Coexpression of Cux-1 and Notch signaling pathway components during kidney development Developmental Dynamics. 2004;231(4):828-838.

Brantley J.G., Sharma M., Alcalay N.I., Vanden Heuvel G.B. Cux-1 transgenic mice develop glomerulosclerosis and interstitial fibrosis Kidney International. 2003;63(4):1240-1248.

Goyal S., Vanden Heuyel G., Aronson P.S. Renal expression of novel Na⁺/H⁺ exchanger isoform NHE8 American Journal of Physiology - Renal Physiology. 2003;284(3 53-3)

Iulianella A., Vanden Heuvel G., Trainor P. Dynamic expression of murine Cux2 in craniofacial, limb, urogenital and neuronal primordia Gene Expression Patterns. 2003;3(5):571-577.

Ledford A., Brantley J.G., Kemeny G., Foreman T., Quaggin S.E., Igarashi P., Oberhaus S.M., Rodova M., Calvet J.P., Vanden Heuvel G.B. Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27^kip1 expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia Developmental Biology. 2002;245(1):157-171.

Quaggin S., Vanden Heuvel G., Igarashi P. Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney Mechanisms of Development. 1998;71(1-2):37-48.

Taylor H.S., Vanden Heuvel G.B., Igarashi P. A conserved Hox axis in the mouse and human female reproductive system: Late establishment and persistent adult expression of the Hoxa cluster genes Biology of Reproduction. 1997;57(6):1338-1345.

Quaggin S.E., Vanden Heuvel G.B., Golden K., Bodmer R., Igarashi P. Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut Journal of Biological Chemistry. 1996;271(37):22624-22634.

Vanden Heuvel G.B., Bodmer R., Mcconnell K.R., Nagami G.T., Igarashi P. Expression of a cut-related homeobox gene in developing and polycystic mouse kidney Kidney International. 1996;50(2):453-461.

Vanden Heuvel G.B., Leardkamolkarn V., St. John P.L., Abrahamson D.R. Carboxy terminal sequence and synthesis of rat kidney laminin γ1 chain Kidney International. 1996;49(3):752-760.

Vanden Heuvel G.B., Quaggin S.E., Igarashi P. A unique variant of a homeobox gene related to Drosophila cut is expressed in mouse testis Biology of Reproduction. 1996;55(4):731-739.

Igarashi P., Vanden Heuvel G.B., Payne J.A., Forbush B. Cloning, embryonic expression, and alternative splicing of a murine kidney-specific Na-K-Cl cotransporter American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1995;269(3 38-3)

Vanden Heuvel G.B., Abrahamson D.R. Quantitation and localization of laminin A, B1, and B2 chain RNA transcripts in developing kidney American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1993;265(2 34-2)