
Chair, Department of Investigative Medicine
Professor, Department of Investigative Medicine
Biosketch
Thomas L. Rothstein obtained his MD and PhD degrees through the Medical Scientist Training Program at Duke University. He completed advanced clinical training in Internal Medicine and Hematology/Oncology at The George Washington University Hospital in Washington, DC and Beth Israel Hospital/Harvard Medical School in Boston, MA. He undertook advanced research training at the National Cancer Institute in Bethesda, MD and the Massachusetts Institute of Technology in Cambridge, MA.
He was appointed Assistant Professor of Medicine and Assistant Professor of Microbiology and Immunology at Boston University School of Medicine/Boston Medical Center (Boston, MA) and rose to the position of full Professor, filling roles as Associate Chief for Research in the Section of Hematology/Oncology, as Director of the Immunobiology Unit, and as Director of the T32 Hematology Training Grant. He was subsequently recruited to the Feinstein Institute for Medical Research (Manhasset, MA) as Investigator, Professor in the Elmezzi Graduate School of Molecular Medicine, and Head of the Center for Oncology and Cell Biology.
Dr. Rothstein was named Director of the Center for Immunobiology, and Professor and Founding Chair, Department of Investigative Medicine at WMed.
Throughout his research career Dr. Rothstein has been continuously funded by the NIH, and has also received grants from the Lupus Research Institute, and the American Cancer Society. He has mentored over 50 graduate students and postdoctoral fellows in his laboratory. He has served on mulitiple review panels for NIH, the Arthritis Foundation, and the Lupus Research Institute.
He is an elected member of the American Society for Clinical Investigation, the Association of American Physicians, and the Kunkel Society. Among his editorial duties he is Editor-in-Chief of Frontiers in B Cell Biology and a member of the editorial board for Cellular Immunology. He serves on the scientific advisory board for the Immunotherapy conferences sponsored by the Center for Molecular Immunology in Havana, Cuba, and was co-organizer for the Merinoff Symposium 2014: B-1 Cell Development and Function.
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Board Certification
- American Board of Internal Medicine (Internal Medicine)
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Education and Training
- Research Fellowship 1981, Medicine, Harvard University
- Fellowship 1981, Hematology and Oncology, Beth Israel Hospital
- Clinical Fellowship 1980, Medicine, Harvard University
- Residency 1979, Medicine, Beth Israel Hospital, Harvard University
- Postdoctoral Fellowship 1977, Biochemistry, Laboratory of Biochemistry, National Cancer Institute
- Internship 1975, Medicine, The George Washington University Hospital, George Washington University
- PhD 1974, Physiology, Duke University
- MD 1974, Medicine, Duke University - School of Medicine, Duke University
- No Degree 1970, Chemistry, George Washington University
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Publications
Kushwaha S., Jawahar V., Kumar A., Griffin L., Rothstein T.L., Sehgal D., Khan N. Complete primer set for amplification and expression of full-length recombinant human monoclonal antibodies from single human B cells Journal of Immunological Methods. 2025;538
Khan N., Hu Y., Lowell C.A., Rothstein T.L. TLR Engagement Induces an Alternate Pathway for BCR Signaling that Results in PKCδ Phosphorylation Journal of Immunology. 2024;212(11):1639-1646.
Gutknecht M.F., Holodick N.E., Rothstein T.L. B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells iScience. 2023;26
Ray M.E., Rothstein T.L. Human VH4-34 antibodies derived from B1 cells are more frequently autoreactive than VH4-34 antibodies derived from memory cells Frontiers in Immunology. 2023;14
Gutknecht M.F., Kaku H., Rothstein T.L. Microparticle immunocapture assay for quantitation of protein multimer amount and size Cell Reports Methods. 2022;2
Husain-Krautter S., Lee J., Vos D., Gallego J.A., Malhotra A.K., Rothstein T.L. Skewing of the antibody repertoire in cerebrospinal fluid B cells from healthy controls and patients with schizophrenia Behavioural Brain Research. 2022;422
Kaku H., Balaj A.R., Rothstein T.L. Small Heat Shock Proteins Collaborate with FAIM to Prevent Accumulation of Misfolded Protein Aggregates International Journal of Molecular Sciences. 2022;23(19)
Rodriguez-Zhurbenko N., Quach T.D., Rothstein T.L., Hernandez A.M. Human B-1 cells are important contributors to the naturally-occurring IgM pool against the tumor-associated ganglioside Neu5GcGM3 Frontiers in Immunology. 2022;13
Srikakulapu P., Pattarabanjird T., Upadhye A., Bontha S.V., Osinski V., Marshall M.A., Garmey J., Deroissart J., Prohaska T.A., Witztum J.L., Binder C.J., Holodick N.E., Rothstein T.L., McNamara C.A. B-1b Cells Have Unique Functional Traits Compared to B-1a Cells at Homeostasis and in Aged Hyperlipidemic Mice With Atherosclerosis Frontiers in Immunology. 2022;13
Kaku H., Ludlow A.V., Gutknecht M.F., Rothstein T.L. Fas Apoptosis Inhibitory Molecule Blocks and Dissolves Pathological Amyloid-β Species Frontiers in Molecular Neuroscience. 2021;14
Khan N., Hu Y., Lowell C.A., Rothstein T.L. Signal integration by translocation and phosphorylation of PKCd in the B Cell alternate pathway Journal of Immunology. 2021;207(9):2288-2296.
Khan N., Rothstein T.L. The Alternate Pathway for BCR Signaling Induced by IL-4 Requires Lyn Tyrosine Kinase Journal of Molecular Biology. 2021;433(1)
Ludlow A., George N., Glassford M., Udenberg K., Hannibal M.C., Schwalm C., Scott K., Rothstein T.L., Singh S.A. The Use of B-Cell Polysome Profiling to Validate Novel RPL5 (uL18) and RPL26 (uL24) Variants in Diamond-Blackfan Anemia Journal of Pediatric Hematology/Oncology. 2021;43:e336-e340.
Yu L., Lemay P., Ludlow A., Guyot M.C., Jones M., Mohamed F.F., Saroya G.A., Panaretos C., Schneider E., Wang Y., Myers G., Khoriaty R., Li Q., Franceschi R., Engel J.D., Kaartinen V., Rothstein T.L., Justice M.J., Kibar Z., Singh S.A. A new murine Rpl5 (uL18) mutation provides a unique model of variably penetrant Diamond-Blackfan anemia Blood Advances. 2021;5:4167-4178.
Kaku H., Ludlow A.V., Gutknecht M.F., Rothstein T.L. FAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis Frontiers in Neuroscience. 2020;14
Kaku H., Ludlow A.V., Gutknecht M.F., Rothstein T.L. FAIM Opposes Aggregation of Mutant SOD1 That Typifies Some Forms of Familial Amyotrophic Lateral Sclerosis Frontiers in Neuroscience. 2020;14
Kaku H., Rothstein T.L. FAIM Is a Non-redundant Defender of Cellular Viability in the Face of Heat and Oxidative Stress and Interferes With Accumulation of Stress-Induced Protein Aggregates Frontiers in Molecular Biosciences. 2020;7
Ghosn E., Dorshkind K., Herzenberg L.A., Holodick N., Kantor A., Montecino-Rodriguez E., Rothstein T.L., Silverman G., Yang Y., Yoder M.C., Yoshimoto M. B1 B cell progenitors Science. 2019;364:248.
Guo B., Ludlow A.V., Brightwell A.S., Rothstein T.L. Impairment of PD-L2 positive B1a cells enhances susceptibility to sepsis in RasGRP1-deficient mice Cellular Immunology. 2019;346
Rodriguez-Zhurbenko N., Quach T.D., Hopkins T.J., Rothstein T.L., Hernandez A.M. Human B-1 cells and B-1 cell antibodies change with advancing age Frontiers in Immunology. 2019;10(MAR)
Upadhye A., Srikakulapu P., Gonen A., Hendrikx S., Perry H.M., Nguyen A., McSkimming C., Marshall M.A., Garmey J.C., Taylor A.M., Bender T.P., Tsimikas S., Holodick N.E., Rothstein T.L., Witztum J.L., McNamara C.A. Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis Circulation research. 2019;125:e55-e70.
Aziz M., Ode Y., Zhou M., Ochani M., Holodick N.E., Rothstein T.L., Wang P. B-1a cells protect mice from sepsis-induced acute lung injury Molecular Medicine. 2018;24
Gallego J.A., Blanco E.A., Husain-Krautter S., Madeline Fagen E., Moreno-Merino P., del Ojo-Jiménez J.A., Ahmed A., Rothstein T.L., Lencz T., Malhotra A.K. Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: New data and an updated meta-analysis Schizophrenia Research. 2018;202:64-71.
Huang W., Quach T.D., Dascalu C., Liu Z., Leung T., Byrne-Steele M., Pan W., Yang Q., Han J., Lesser M., Rothstein T.L., Furie R., Mackay M., Aranow C., Davidson A. Belimumab promotes negative selection of activated autoreactive B cells in systemic lupus erythematosus patients JCI insight. 2018;3(17)
Aziz M., Holodick N., Rothstein T., Wang P. B-1a cells protect mice from sepsis: Critical role of creb Journal of Immunology. 2017;199(2):750-760.
Kaku H., Holodick N., Tumang J., Rothstein T. CD25<sup>+</sup> B-1a cells express Aicda Frontiers in Immunology. 2017;8
Cui X., Zhang L., Magli A.R., Catera R., Yan X.J., Griffin D.O., Rothstein T.L., Barrientos J., Kolitz J.E., Allen S.L., Rai K.R., Chiorazzi N., Chu C.C. Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability Leukemia. 2016;30(1):74-85.
Guo B., Rothstein T. RasGRP1 is an essential signaling molecule for development of B1a cells with autoantigen receptors Journal of Immunology. 2016;196:2583-2590.
Guo B., Zhang L., Chiorazzi N., Rothstein T.L. IL-4 rescues surface IgM expression in chronic lymphocytic leukemia Blood. 2016;128:553-562.
Holodick N., Vizconde T., Hopkins T., Rothstein T. Age-related decline in natural igm function: Diversification and selection of the B-1a cell pool with age Journal of Immunology. 2016;196(10):4348-4357.
Holodick N.E., Zeumer L., Rothstein T.L., Morel L. Expansion of B-1a cells with germline heavy chain sequence in lupus mice Frontiers in Immunology. 2016;7(MAR)
Kramer J.M., Holodick N.E., Vizconde T.C., Raman I., Yan M., Li Q.Z., Gaile D.P., Rothstein T.L. Analysis of IgM antibody production and repertoire in a mouse model of Sjögren’s syndrome Journal of Leukocyte Biology. 2016;99(2):321-331.
Olofsson P.S., Steinberg B., Sobbi R., Cox M.A., Ahmed M.N., Oswald M., Szekeres F., Hanes W.M., Introini A., Liu S.F., Holodick N.E., Rothstein T.L., Lövdahl C., Chavan S.S., Yang H., Pavlov V.A., Broliden K., Andersson U., Diamond B., Miller E.J., Arner A., Gregersen P.K., Backx P.H., Mak T.W., Tracey K.J. Blood pressure regulation by CD4<sup>+</sup> lymphocytes expressing choline acetyltransferase Nature Biotechnology. 2016;34(10):1066-1071.
Quach T.D., Rodriguez-Zhurbenko N., Hopkins T.J., Guo X., Hernandez A.M., Li W., Rothstein T.L. Distinctions among circulating antibody-secreting cell populations, including B-1 cells, in human adult peripheral blood Journal of Immunology. 2016;196(3):1060-1069.
Quách T.D., Hopkins T.J., Holodick N.E., Vuyyuru R., Manser T., Bayer R.L., Rothstein T.L. Human B-1 and B-2 B cells develop from Lin<sup>-</sup>CD34<sup>+</sup>CD38<sup>lo</sup> stem cells Journal of Immunology. 2016;197(10):3950-3958.
Rothstein T. Natural antibodies as rheostats for susceptibility to chronic diseases in the aged Frontiers in Immunology. 2016;7(APR)
Rothstein T., Holodick N. Activation of B-1 Cells Encyclopedia of Immunobiology. 2016;3:237-243.
Sharma A., Kiripolsky J., Klimatcheva E., Howell A., Fereidouni F., Levenson R., Rothstein T.L., Kramer J.M. Early BAFF receptor blockade mitigates murine Sjögren's syndrome: Concomitant targeting of CXCL13 and the BAFF receptor prevents salivary hypofunction Clinical Immunology. 2016;164:85-94.
Aziz M., Holodick N.E., Rothstein T.L., Wang P. The role of B-1 cells in inflammation Immunologic Research. 2015;63(1-3):153-166.
Engelbertsen D., Vallejo J., Dan Quách T., Fredrikson G.N., Alm R., Hedblad B., Björkbacka H., Rothstein T.L., Nilsson J., Bengtsson E. Low levels of IgM antibodies against an advanced glycation endproduct-modified apolipoprotein B100 peptide predict cardiovascular events in nondiabetic subjects Journal of Immunology. 2015;195(7):3020-3025.
Holodick N., Rothstein T. B cells in the aging immune system: Time to consider B-1 cells Annals of the New York Academy of Sciences. 2015;1362(1):176-187.
Husain-Krautter S., Kramer J.M., Li W., Guo B., Rothstein T.L. The osteopontin transgenic mouse is a new model for Sjögren's syndrome Clinical Immunology. 2015;157:30-42.
Rothstein T., Herzenberg L., Holodick N., Ghosn E. B-1 Cell Development and Function Annals of the New York Academy of Sciences. 2015;1362(1):v-vi.
Rothstein T., Quach T. The human counterpart of mouse B-1 cells Annals of the New York Academy of Sciences. 2015;1362(1):143-152.
Holodick N., Vizconde T., Rothstein T. B-1a Cell diversity: Nontemplated addition in B-1a cell ig is determined by progenitor population and developmental location Journal of Immunology. 2014;192(5):2432-2441.
Holodick N., Vizconde T., Rothstein T. Splenic B-1a cells expressing CD138 spontaneously secrete large amounts of immunoglobulin in naïve mice Frontiers in Immunology. 2014;5(MAR)
Kaku H., Cheng K.F., Al-Abed Y., Rothstein T.L. A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production Journal of Immunology. 2014;193:5904-5913.
Weber G.F., Chousterman B.G., Hilgendorf I., Robbins C.S., Theurl I., Gerhardt L.M.S., Iwamoto Y., Quach T.D., Ali M., Chen J.W., Rothstein T.L., Nahrendorf M., Weissleder R., Swirski F.K. Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis Journal of Experimental Medicine. 2014;211(6):1243-1256.
Chen S., Batliwalla F., Holodick N., Yan X., Yancopoulos S., Croce C., Rothstein T., Chiorazzi N. Autoantigen can promote progression to a more aggressive TCL1 leukemia by selecting variants with enhanced B-cell receptor signaling Proceedings of the National Academy of Sciences of the United States of America. 2013;110(16)
Guo B., Rothstein T. IL-4 upregulates Igα and Igβ protein, resulting in augmented IgM maturation and B cell receptor-triggered B cell activation Journal of Immunology. 2013;191:670-677.
Guo B., Rothstein T.L. A novel Lyn-protein kinase Cδ/ε-protein kinase D axis is activated in B cells by signalosome-independent alternate pathway BCR signaling European Journal of Immunology. 2013;43:1643-1650.
Holodick N., Rothstein T. Atypical response of B-1 cells to BCR ligation: A speculative model Frontiers in Immunology. 2013;4(DEC)
Kramer J., Klimatcheva E., Rothstein T. CXCL13 is elevated in Sjögren's syndrome in mice and humans and is implicated in disease pathogenesis Journal of Leukocyte Biology. 2013;94(5):1079-1089.
Li W., Batliwalla F., Rothstein T.L. Human B-1 cells are not preplasmablasts: Analysis of microarray data and other issues Blood. 2013;122(22):3691-3693.
Rothstein T., Griffin D., Holodick N., Quach T., Kaku H. Human B-1 cells take the stage Annals of the New York Academy of Sciences. 2013;1285:97-114.
Griffin D., Quach T., Batliwalla F., Andreopoulos D., Holodick N., Rothstein T. Human CD11b<sup>+</sup> B1 cells are not monocytes: A reply to "Gene profiling of CD11b<sup>+</sup> and CD11b<sup>-</sup> B1 cell subsets reveals potential cell sorting artifacts" Journal of Experimental Medicine. 2012;209(3):434-436.
Griffin D., Rothstein T. Human B1 cell frequency: Isolation and analysis of human B1 cells Frontiers in Immunology. 2012;3(MAY)
Griffin D.O., Rothstein T.L. Human "orchestrator" CD11b(+) B1 cells spontaneously secrete interleukin-10 and regulate T-cell activity. Molecular medicine (Cambridge, Mass.). 2012;18:1003-1008.
Wang Y., Rothstein T. Induction of Th17 cell differentiation by B-1 cells Frontiers in Immunology. 2012;3(SEP)
Griffin D., Holodick N., Rothstein T. Correction: Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20<sup>+</sup>CD27<sup>+</sup>CD43<sup>+</sup>CD70<sup>-</sup> Journal of Experimental Medicine. 2011;208(4):871.
Griffin D., Holodick N., Rothstein T. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20<sup>+</sup>CD27<sup>+</sup>CD43<sup>+</sup>CD70<sup>-</sup> Journal of Experimental Medicine. 2011;208(1):67-80.
Griffin D., Holodick N., Rothstein T. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20<sup>+</sup>CD27<sup>+</sup>CD43<sup>+</sup>CD70<sup>-</sup> (The Journal of Experimental Medicine (2011), 208, 1, (67-80)) Journal of Experimental Medicine. 2011;208(2):409.
Griffin D., Rothstein T. A small cd11b <sup>+</sup> human B1 cell subpopulation stimulates T cells and is expanded in lupus Journal of Experimental Medicine. 2011;208(13):2591-2598.
Griffin D.O., Holodick N.E., Rothstein T.L. Human B1 cells are CD3<sup>-</sup>: A reply to "A human equivalent of mouse B-1 cells?" and "The nature of circulating CD27<sup>+</sup>CD43<sup>+</sup> B cells" Journal of Experimental Medicine. 2011;208(13):2566-2569.
Rothstein T. Grand challenges in B cell biology Frontiers in Immunology. 2011;2(FEB)
Tumang J.R., Holodick N.E., Vizconde T.C., Kaku H., Francés R., Rothstein T.L. A CD25<sup>-</sup> positive population of activated B1 cells expresses LIFR and responds to LIF Frontiers in Immunology. 2011;2
Zhong X., Rothstein T.L. L2pB1: A new player in autoimmunity Molecular Immunology. 2011;48(11):1292-1300.
Holodick N., Tumang J., Rothstein T. Immunoglobulin secretion by B1 cells: Differential intensity and IRF4-dependence of spontaneous IgM secretion by peritoneal and splenic B1 cells European Journal of Immunology. 2010;40(11):3007-3016.
Kaku H., Rothstein T.L. Fas apoptosis inhibitory molecule enhances CD40 signaling in B cells and augments the plasma cell compartment (Journal of Immunology (2009) 183, (1667-1674)) Journal of Immunology. 2010;185:771.
Kaku H., Rothstein T.L. Octamer binding protein 2 (Oct2) regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique, intronic promoter Genes and Immunity. 2010;11:55-66.
Guo B., Tumang J., Rothstein T. B cell receptor crosstalk: B cells express osteopontin through the combined action of the alternate and classical BCR signaling pathways Molecular Immunology. 2009;46:587-591.
Hemond M., Rothstein T.L., Wagner G. Fas Apoptosis Inhibitory Molecule Contains a Novel β-Sandwich in Contact with a Partially Ordered Domain Journal of Molecular Biology. 2009;386(4):1024-1037.
Holodick N., Tumang J., Rothstein T. Continual signaling is responsible for constitutive ERK phosphorylation in B-1a cells Molecular Immunology. 2009;46(15):3029-3036.
Holodick N.E., Repetny K., Zhong X., Rothstein T.L. Adult BM generates CD5<sup>+</sup> B1 cells containing abundant N-region additions European Journal of Immunology. 2009;39(9):2383-2394.
Kaku H., Rothstein T. Fas apoptosis inhibitory molecule enhances CD40 signaling in B cells and augments the plasma cell compartment Journal of Immunology. 2009;183:1667-1674.
Kaku H., Rothstein T. Fas apoptosis inhibitory molecule expression in B cells is regulated through IRF4 in a feed-forward mechanism Journal of Immunology. 2009;183:5575-5581.
Repetny K.J., Zhong X., Holodick N.E., Rothstein T.L., Hansen U. Binding of LBP-1a to specific immunoglobulin switch regions in vivo correlates with specific repression of class switch recombination European Journal of Immunology. 2009;39(5):1387-1394.
Rothstein T., Guo B. Receptor crosstalk: Reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontin Journal of Internal Medicine. 2009;265:632-643.
Zhong X., Lau S., Bai C., Degauque N., Holodick N., Steven S., Tumang J., Gao W., Rothstein T. A novel subpopulation of B-1 cells is enriched with autoreactivity in normal and lupus-prone mice Arthritis and Rheumatism. 2009;60(12):3734-3743.
Busconi L., Bauer J.W., Tumang J.R., Laws A., Perkins-Mesires K., Tabor A.S., Lau C., Corley R.B., Rothstein T.L., Lund F.E., Behrens T.W., Marshak-Rothstein A. Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9 Journal of Immunology. 2007;179(11):7397-7405.
Dye J.R., Palvanov A., Guo B., Rothstein T.L. B cell receptor cross-talk: Exposure to lipopolysaccharide induces an alternate pathway for B cell receptor-induced ERK phosphorylation and NF-κB activation Journal of Immunology. 2007;179:229-235.
Francés R., Tumang J.R., Rothstein T.L. Extreme skewing of annexin II and S100A6 expression identified by proteomic analysis of peritoneal B-1 cells International Immunology. 2007;19(1):59-65.
Guo B., Blair D., Chiles T.C., Lowell C.A., Rothstein T.L. Cutting edge: B cell receptor (BCR) cross-talk: The IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to rottlerin, and depends on Lyn Journal of Immunology. 2007;178:4726-4730.
Mineva N.D., Rothstein T.L., Meyers J.A., Lerner A., Sonenshein G.E. CD40 ligand-mediated activation of the de novo RelB NF-κB synthesis pathway in transformed B cells promotes rescue from apoptosis Journal of Biological Chemistry. 2007;282(24):17475-17485.
Zhong X., Gao W., Degauque N., Bai C., Lu Y., Kenny J., Oukka M., Strom T.B., Rothstein T.L. Reciprocal generation of Th1/Th17 and T<inf>reg</inf> cells by B1 and B2 B cells European Journal of Immunology. 2007;37(9):2400-2404.
Zhong X., Tumang J.R., Gao W., Bai C., Rothstein T.L., Rothstein T.L. PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V<inf>H</inf>11/V<inf>H</inf>12 and phosphatidylcholine binding European Journal of Immunology. 2007;37(9):2405-2410.
Francés R., Tumang J., Kaku H., Gurdak S., Rothstein T. B-1 cells express transgelin 2: Unexpected lymphocyte expression of a smooth muscle protein identified by proteomic analysis of peritoneal B-1 cells Molecular Immunology. 2006;43:2124-2129.
Hastings W., Gurdak S., Tumang J., Rothstein T. CD5<sup>+</sup>/Mac-1<sup>-</sup> peritoneal B cells: A novel B cell subset that exhibits characteristics of B-1 cells Immunology Letters. 2006;105(1):90-96.
Hastings W.D., Tumang J.R., Behrens T.W., Rothstein T.L. Peritoneal B-2 cells comprise a distinct B-2 cell population with B-1b-like characteristics European Journal of Immunology. 2006;36(5):1114-1123.
Mataraza J., Tumang J., Gumina M., Gurdak S., Rothstein T., Chiles T. Disruption of cyclin D3 blocks proliferation of normal B-1a cells, but loss of cyclin D3 is compensated by cyclin D2 in cyclin D3-deficient mice Journal of Immunology. 2006;177(2):787-795.
Rosenbauer F., Owens B.M., Yu L., Tumang J.R., Steidl U., Kutok J.L., Clayton L.K., Wagner K., Scheller M., Iwasaki H., Liu C., Hackanson B., Akashi K., Leutz A., Rothstein T.L., Plass C., Tenen D.G. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1 Nature Genetics. 2006;38(1):27-37.
Seung G.Y., Tumang J.R., Rothstein T.L. Characteristic features of B cells in murine cervical lymph nodes Acta Oto-Laryngologica. 2006;126(1):56-61.
Barrington R.A., Zhang M., Zhong X., Jonsson H., Holodick N., Cherukuri A., Pierce S.K., Rothstein T.L., Carroll M.C. CD21/CD19 coreceptor signaling promotes B cell survival during primary immune responses Journal of Immunology. 2005;175(5):2859-2867.
Francés R., Tumang J., Rothstein T. Cutting edge: B-1 cells are deficient in Lck: Defective B cell receptor signal transduction in B-1 cells occurs in the absence of elevated Lck expression Journal of Immunology. 2005;175(1):27-31.
Guo B., Rothstein T. B Cell Receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is phosphatidylinositol 3-kinase independent Journal of Immunology. 2005;174:5375-5381.
Mizuno T., Rothstein T.L. B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates IκB kinase/IκBα/NF- κB without the need for PI3K and phospholipase Cγ Journal of Immunology. 2005;174(10):6062-6070.
Mizuno T., Rothstein T.L. B cell receptor (BCR) cross-talk: CD40 engagement enhances BCR-induced ERK activation Journal of Immunology. 2005;174(6):3369-3376.
Tumang J.R., Francés R., Yeo S.G., Rothstein T.L. Cutting edge: Spontaneously Ig-secreting B-1 cells violate the accepted paradigm for expression of differentiation-associated transcription factors Journal of Immunology. 2005;174(6):3173-3177.
Foote L.C., Evans J.W., Cifuni J.M., Siracusa M.C., Monteforte G.M., McCole J.L., D'Orazio C.C., Hastings W.D., Rothstein T.L. Interleukin-4 produces a breakdown of tolerance in vivo with autoantibody formation and tissue damage Autoimmunity. 2004;37(8):569-577.
Greenwald R.J., Tumang J.R., Sinha A., Currier N., Cardiff R.D., Rothstein T.L., Faller D.V., Denis G.V. Eμ-BRD2 transgenic mice develop B-cell lymphoma and leukemia Blood. 2004;103(4):1475-1484.
Piatelli M.J., Wardle C., Blois J., Doughty C., Schram B.R., Rothstein T.L., Chiles T.C. Phosphatidylinositol 3-Kinase-Dependent Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1/2 and NF-κB Signaling Pathways Are Required for B Cell Antigen Receptor-Mediated Cyclin D2 Induction in Mature B Cells Journal of Immunology. 2004;172(5):2753-2762.
Tumang J., Hastings W., Bai C., Rothstein T. Peritoneal and splenic B-1 cells are separable by phenotypic, functional, and transcriptomic characteristics European Journal of Immunology. 2004;34(8):2158-2167.
Zhong X., Chunyan B., Gao W., Strom T.B., Rothstein T.L. Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger International Immunology. 2004;16(8):1181-1188.
Mizuno T., Rothstein T.L. Cutting edge: CD40 engagement eliminates the need for Bruton's tyrosine kinase in B cell receptor signaling for NF-κB Journal of Immunology. 2003;170(6):2806-2810.
Mizuno T., Zhong X., Rothstein T. Fas-induced apoptosis in B cells Apoptosis. 2003;8(5):451-460.
Piatelli M.J., Tanguay D., Rothstein T.L., Chiles T.C. Cell cycle control mechanisms in b-1 and b-2 lymphoid subsets Immunologic Research. 2003;27(1):31-51.
Schram B.R., Rothstein T.L. NF-κB is required for surface Ig-induced Fas resistance in B cells Journal of Immunology. 2003;170(6):3118-3124.
Irigoyen M., Mizuno T., Zhong X., Negm R.S., Schneider T.J., Rothstein T.L. B cell activation leads to upregulated expression of the murine Sik-similar protein gene Molecular Immunology. 2002;38(11):861-866.
Rothstein T. Cutting edge commentary: Two B-1 or not to be one Journal of Immunology. 2002;168(9):4257-4261.
Tumang J., Negm R., Solt L., Schneider T., Colarusso T., Hastings W., Woodland R., Rothstein T. BCR engagement induces Fas resistance in primary B cells in the absence of functional Bruton's tyrosine kinase Journal of Immunology. 2002;168(6):2712-2719.
Wurster A.L., Rodgers V.L., White M.F., Rothstein T.L., Grusby M.J. Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL Journal of Biological Chemistry. 2002;277(30):27169-27175.
Fan H., Rothstein T.L. Lymphokine dependence of STAT3 activation produced by surface immunoglobulin cross-linking and by phorbol ester plus calcium ionophore treatment in B cells European Journal of Immunology. 2001;31(2):665-671.
Fischer G.M., Solt L.A., Hastings W.D., Yang K., Gerstein R.M., Nikolajczyk B.S., Clarke S.H., Rothstein T.L. Splenic and peritoneal B-1 cells differ in terms of transcriptional and proliferative features that separate peritoneal B-1 from splenic B-2 cells Cellular Immunology. 2001;213(1):62-71.
Owyang A.M., Tumang J.R., Schram B.R., Hsia C.Y., Behrens T.W., Rothstein T.L., Liou H.C. c-Rel is required for the protection of B cells from antigen receptor-mediated, but not fas-mediated, apoptosis Journal of Immunology. 2001;167(9):4948-4956.
Tanguay D.A., Colarusso T.P., Doughty C., Pavlovic-Ewers S., Rothstein T.L., Chiles T.C. Cutting edge: Differential signaling requirements for activation of assembled cyclin D3-cdk4 complexes in B-1 and B-2 lymphocyte subsets Journal of Immunology. 2001;166(7):4273-4277.
Zhong X., Schneider T.J., Cabral D.S., Donohoe T.J., Rothstein T.L. An alternatively spliced long form of Fas apoptosis inhibitory molecule (FAIM) with tissue-specific expression in the brain Molecular Immunology. 2001;38(1):65-72.
Karras J.G., McKay R.A., Lu T., Pych J., Frank D.A., Rothstein T.L., Monia B.P. STAT3 regulates the growth and immunoglobulin production of BCL<inf>1</inf> B cell lymphoma through control of cell cycle progression Cellular Immunology. 2000;202(2):124-135.
Rothstein T.L. Inducible resistance to Fas-mediated apoptosis in B cells Cell Research. 2000;10(4):245-266.
Rothstein T.L., Fischer G.M., Tanguay D.A., Pavlovic S., Colarusso T.P., Gerstein R.M., Clarke S.H., Chiles T.C. STAT3 activation, chemokine receptor expression, and cyclin-Cdk function in B-1 cells Current Topics in Microbiology and Immunology. 2000;252:121-130.
Rothstein T.L., Zhong X., Schram B.R., Negm R.S., Donohoe T.J., Cabral D.S., Foote L.C., Schneider T.J. Receptor-specific regulation of B-cell susceptibility to Fas-mediated apoptosis and a novel Fas apoptosis inhibitory molecule Immunological Reviews. 2000;176:116-133.
Schneider T.J., Fischer G.M., Donohoe T.J., Colarusso T.P., Rothstein T.L. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes Journal of Experimental Medicine. 1999;189(6):949-955.
Tanguay D.A., Colarusso T.P., Pavlovic S., Irigoyen M., Howard R.G., Bartek J., Chiles T.C., Rothstein T.L. Early induction of cyclin D2 expression in phorbol ester-responsive B-1 lymphocytes Journal of Experimental Medicine. 1999;189(11):1685-1690.
Foote L.C., Marshak-Rothstein A., Rothstein T.L. Tolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded Journal of Experimental Medicine. 1998;187(6):847-853.
Francis D.A., Sen R., Rice N., Rothstein T.L. Receptor-specific induction of NF-κB components in primary B cells International Immunology. 1998;10(3):285-293.
Fine A., Anderson N.L., Rothstein T.L., Williams M.C., Gochuico B.R. Fas expression in pulmonary alveolar type II cells American Journal of Physiology - Lung Cellular and Molecular Physiology. 1997;273(1 17-1)
Foote L., Marshak-Rothstein A., Rothstein T. Inducible Fas-resistance mediated by IL-4 in activated B cells Annals of the New York Academy of Sciences. 1997;815:114-115.
Francis D.A., Sen R., Rothstein T.L. Receptor-specific regulation of NF-κB, c-Myc and Fas-mediated apoptosis in primary B cells Current Topics in Microbiology and Immunology. 1997;224:83-90.
Jacobson B.A., Foote L.C., Panka D.J., Ju S.T., Rothstein T.L., Marshak-Rothstein A. Unique site of autoantibody production in Fas-deficient mice Annals of the New York Academy of Sciences. 1997;815:218-229.
Jacobson B.A., Rothstein T.L., Marshak-Rothstein A. Unique site of IgG2a and rheumatoid factor production in MRL/lpr mice Immunological Reviews. 1997;156:103-110.
Karras J.G., Wang Z., Huo L., Frank D.A., Rothstein T.L. Induction of STAT Protein Signaling Through the CD40 Receptor in B Lymphocytes: Distinct STAT Activation Following Surface Ig and CD40 Receptor Engagement Journal of Immunology. 1997;159(9):4350-4355.
Karras J.G., Wang Z., Huo L., Howard R.G., Frank D.A., Rothstein T.L. Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes Journal of Experimental Medicine. 1997;185(6):1035-1042.
Schneider T.J., Grillot D., Foote L.C., Núñez G.E., Rothstein T.L. Bcl-x Protects Primary B Cells Against Fas- Mediated Apoptosis Journal of Immunology. 1997;159(10):4834-4839.
Wang Z., Karras J., Colarusso T., Foote L., Rothstein T. Unmethylated CpG motifs protect murine B lymphocytes against Fas- mediated apoptosis Cellular Immunology. 1997;180(2):162-167.
Ahearn J.M., Fischer M.B., Croix D., Goerg S., Ma M., Xia J., Zhou X., Howard R.G., Rothstein T.L., Carroll M.C. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen Immunity. 1996;4(3):251-262.
Fischer M.B., Ma M., Goerg S., Zhou X., Xia J., Finco O., Han S., Kelsoe G., Howard R.G., Rothstein T.L., Kremmer E., Rosen F.S., Carroll M.C. Regulation of the B cell response to T-dependent antigens by classical pathway complement Journal of Immunology. 1996;157(2):549-556.
Foote L.C., Howard R.G., Marshak-Rothstein A., Rothstein T.L. IL-4 Induces Fas Resistance in B Cells Journal of Immunology. 1996;157(7):2749-2753.
Foote L.C., Schneider T.J., Fischer G.M., Wang J.K.M., Rasmussen B., Campbell K.A., Lynch D.H., Ju S.T., Marshak-Rothstein A., Rothstein T.L. Intracellular Signaling for Inducible Antigen Receptor-Mediated Fas Resistance in B Cells Journal of Immunology. 1996;157(5):1878-1885.
Huo L., Rothstein T.L. Isolation and Characterization of Murine fra-1: Induction Mediated by CD40 and Surface Ig Is Protein Kinase C Dependent Journal of Immunology. 1996;157(9):3812-3818.
Jacobson B., Rothstein T., Marshak-Rothstein A. The role of Fas/FasL interactions in the regulation of B cell function. Behring Institute Mitteilungen. 1996(97):185-199.
Karras J.G., Huo L., Wang Z., Frank D.A., Zimmet J.M., Rothstein T.L. Delayed Tyrosine Phosphorylation and Nuclear Expression of STAT1 Following Antigen Receptor Stimulation of B Lymphocytes Journal of Immunology. 1996;157(6):2299-2309.
Karras J.G., Wang Z., Coniglio S.J., Frank D.A., Rothstein T.L. Antigen-receptor engagement in B cells induces nuclear expression of STAT5 and STAT6 proteins that bind and transactivate an IFN-γ activation site Journal of Immunology. 1996;157(1):39-47.
Ozdemirli M., El-Khatib M., Foote L.C., Wang J.K.M., Marshak-Rothstein A., Rothstein T.L., Ju S.T. Fas (CD95)/Fas ligand interactions regulate antigen-specific, major histocompatibility complex-restricted T/B cell proliferative responses European Journal of Immunology. 1996;26(2):415-419.
Rothstein T. Signals and susceptibility to programmed death in B cells Current Opinion in Immunology. 1996;8(3):362-371.
Rothstein T.L., Foote L.C., Schneider T.J., Fischer G.M., Jacobson B.A., Lynch D.H., Ju S.T., Marshak-Rothstein A. Inducible resistance to Fas-mediated apoptosis in primary B lymphocytes Advances in Experimental Medicine and Biology. 1996;406:177-189.
Schauer S.L., Wang Z., Sonenshein G.E., Rothstein T.L. Maintenance of nuclear factor-κB/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of IκB proteins Journal of Immunology. 1996;157(1):81-86.
Schauer S.L., Wang Z., Wu M., Arsura M., Lee H., Sherr D., Rothstein T.L., Sonenshein G.E. Maintenance of NF-KB/rel and c-myc expression through modulation of 1kb proteins during CD40 ligand rescue of WEHI 231 B FASEB Journal. 1996;10(6)
Wu M., Lee H., Bellas R.E., Schauer S.L., Arsura M., Katz D., Fitzgerald M.J., Rothstein T.L., Sherr D.H., Sonenshein G.E. Inhibition of NF-κB/Rel induces apoptosis of murine B cells EMBO Journal. 1996;15(17):4682-4690.
Xie H., Wang Z., Rothstein T.L. Signaling pathways for antigen receptor-mediated induction of transcription factor CREB in B lymphocytes Cellular Immunology. 1996;169(2):264-270.
Dziennis S., Van Etten R.A., Pahl H.L., Morris D.L., Rothstein T.L., Blosch C.M., Perlmutter R.M., Tenen D.G. The CD11b promoter directs high-level expression of reporter genes in macrophages in transgenic mice Blood. 1995;85(2):319-329.
Francis D.A., Karras J.G., Ke X.y., Sen R., Rothstein T.L. Induction of the transcription factors NF-κB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor International Immunology. 1995;7(2):151-161.
Huo L., Rothstein T.L. Receptor-specific induction of individual AP-1 components in B lymphocytes Journal of Immunology. 1995;154(7):3300-3309.
Morris D., Rothstein T. Analysis of b-1 cell activation Methods: A Companion to Methods in Enzymology. 1995;8(1):11-25.
Rothstein T.L., Wang J.K.M., Panka D.J., Foote L.C., Wang Z., Stanger B., Cui H., Ju S.T., Marshak-Rothstein A. Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells Nature. 1995;374(6518):163-165.
Wang Z., Karras J.G., Howard R.G., Rothstein T.L. Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells Journal of Immunology. 1995;155(8):3722-3725.
Wang Z., Morris D.L., Rothstein T.L. Constitutive and inducible levels of egr-1 and c-myc early growth response gene expression in self-renewing B-1 lymphocytes Cellular Immunology. 1995;162(2):309-314.
Xie H., Rothstein T.L. Protein kinase C mediates activation of nuclear cAMP response element-binding protein (CREB) in B lymphocytes stimulated through surface Ig Journal of Immunology. 1995;154(4):1717-1723.
Huo L., Chung W., Rothstein T. C-terminal sequence of the NF-κB p50 precursor from primary murine B-lymphocytes Gene. 1994;139(2):287-288.
Morris D., Rothstein T. Decreased surface IgM receptor-mediated activation of phospholipase C<inf>γ</inf>2 in B-1 lymphocytes International Immunology. 1994;6(7):1011-1016.
Tanguay D., Tanguay J., McManus B., Huo L., Rothstein T., Chiles T. Activation of AP-1 in primary B lymphocytes by surface immunoglobulin requires de novo Jun-B synthesis Cellular Immunology. 1994;158(2):281-291.
Venkataraman L., Francis D.A., Wang Z., Liu J., Rothstein T.L., Sen R. Cyclosporin-a sensitive induction of NF-AT in murine B cells Immunity. 1994;1(3):189-196.
Lalmanach-Girard A.C., Chiles T.C., Parker D.C., Rothstein T.L. T cell-dependent induction of NF-κB in B cells Journal of Experimental Medicine. 1993;177(4):1215-1219.
Liu J., Sen R., Rothstein T. Abnormal κB-binding protein in the cytoplasm of a plasmacytoma cell line that lacks nuclear expression of NF-κB Molecular Immunology. 1993;30(5):479-489.
Morris D.L., Rothstein T.L. Abnormal transcription factor induction through the surface immunoglobulin M receptor of B-1 lymphocytes Journal of Experimental Medicine. 1993;177(3):857-861.
Xie H., Chiles T.C., Rothstein T.L. Induction of CREB Activity Via the Surface Ig Receptor of B Cells Journal of Immunology. 1993;151(2):880-889.
Chiles T.C., Rothstein T.L. Surface Ig receptor-induced nuclear AP-1-dependent gene expression in B lymphocytes Journal of Immunology. 1992;149(3):825-831.
ROTHSTEIN T., KOLBER D., COHEN D. CD5‐like Phorbol‐Ester Responsiveness in Conventional B Cells Activated through Surface Immunoglobulin Annals of the New York Academy of Sciences. 1992;651(1):176-178.
Wieselthier J.S., Japowicz M.C., Rothstein T.L., Yu T.L., Anderson T., Koh H.K. Inefficacy of extracorporeal photochemotherapy in the treatment of B‐Cell chronic lymphocytic leukemia: Preliminary results American Journal of Hematology. 1992;41(2):123-127.
Chiles T.C., Liu J., Rothstein T.L. Cross-linking of surface Ig receptors on murine B lymphocyte stimulates the expression of nuclear tetradecanoyl phorbol acetate-response element-binding proteins Journal of Immunology. 1991;146(6):1730-1735.
Cohen B.P., Rothstein T.L. Elevated levels of protein kinase C activity and α-isoenzyme expression in murine peritoneal B cells Journal of Immunology. 1991;146(9):2921-2927.
Kolber D.L., Rothstein T.L., Shultz L.D. Phorbol ester responsiveness of murine Ly‐1‐lineage B cells from normal and viable motheaten mutant mice European Journal of Immunology. 1991;21(3):721-729.
Liu J., Chiles T.C., Sen R., Rothstein T.L. Inducible nuclear expression of NF-κB in primary B cells stimulated through the surface Ig receptor Journal of Immunology. 1991;146(5):1685-1691.
Rothstein T.L., Kolber D.L., Murphy T.P., Cohen D.P. Induction of phorbol ester responsiveness in conventional B cells after activation via surface Ig Journal of Immunology. 1991;147(11):3728-3735.
Tilzey J.F., Chiles T.C., Rothstein T.L. Jun-B gene expression mediated by the surface immunoglobulin receptor of primary B lymphocytes Biochemical and Biophysical Research Communications. 1991;175(1):77-83.
Buckler A.J., Rothstein T.L., Sonenshein G.E. Transcriptional control of c-myc gene expression during stimulation of murine B lymphocytes Journal of Immunology. 1990;145(2):732-736.
Miller P., Pothoulakis C., Baeker T., LaMont J., Rothstein T. Macrophage-dependent stimulation of T cell-depleted spleen cells by Clostridium difficile toxin A and calcium ionophore Cellular Immunology. 1990;126(1):155-163.
Murphy T.P., Kolber D.L., Rothstein T.L. Elevated expression of Pgp‐1 (Ly‐24) by murine peritoneal B lymphocytes European Journal of Immunology. 1990;20(5):1137-1142.
Rothstein T.L. Polyreactive low-affinity IgM antibodies produced by CD5+B cells Immunology Today. 1990;11(C):152.
Cohen D.P., Rothstein T.L. Adenosine 3′,5′-cyclic monophosphate modulates the mitogenic responses of murine B lymphocytes Cellular Immunology. 1989;121(1):113-124.
Rothstein T. Interleukin-4 enhances peritoneal B cell stimulation induced by phorbol ester Cellular Immunology. 1989;120(2):450-459.
Wolfowicz C.B., Lyons S., Mahon C.A., Marshak-Rothstein A., Rothstein T.L. Isolation of self-recognizing IgG2a monoclonal rheumatoid factors Clinical Immunology and Immunopathology. 1989;52(2):313-322.
van Haelst-Pisani C., Cragoe E., Rothstein T. Cytoplasmic alkalinization produced by the combination of anti-immunoglobulin antibody plus cytochalasin D in murine B lymphocytes Experimental Cell Research. 1989;183(1):251-256.
Buckler A., Rothstein T., Sonenshein G. Two-step stimulation of B lymphocytes to enter DNA synthesis: Synergy between anti-immunoglobulin antibody and cytochalasin on expression of c-myc and a G<inf>1</inf>-specific gene Molecular and Cellular Biology. 1988;8(3):1371-1375.
Buckler A.J., Kessler D.J., Duyao M.P., Rothstein T.L., Sonenshein G.E. Regulation of c-myc gene transcription in B lymphocytes: mechanisms of negative and positive control. Current topics in microbiology and immunology. 1988;141:238-246.
Rothstein T., Kolber D. Anti-Ig antibody inhibits the phorbol ester-induced stimulation of peritoneal B cells Journal of Immunology. 1988;141(12):4089-4093.
Rothstein T., Kolber D. Peritoneal B cells respond to phorbol esters in the absence of co-mitogen Journal of Immunology. 1988;140(9):2880-2885.
Shlomchik M.J., Marshak-Rothstein A., Wolfowicz C.B., Rothstein T.L., Weigert M.G. The role of clonal selection and somatic mutation in autoimmunity Nature. 1988;328(6133):805-811.
Van Haelst C., Rothstein T. Cytochalasin stimulates phosphoinositide metabolism in murine B lymphocytes Journal of Immunology. 1988;140(4):1256-1258.
Wolfowicz C.B., Sakorafas P., Rothstein T.L., Marshak-Rothstein A. Oligoclonality of rheumatoid factors arising spontaneously in lpr/lpr mice Clinical Immunology and Immunopathology. 1988;46(3):382-395.
Baeker T.R., Simons E.R., Rothstein T.L. Cytochalasin induces an increase in cytosolic free calcium in murine B lymphocytes Journal of Immunology. 1987;138(8):2691-2697.
ROTHSTEIN T., KOLBER D. Two Dual‐Signal Pathways for Stimulation of B Cells Mediated by Calcium Ionophores Annals of the New York Academy of Sciences. 1987;494(1):160-161.
Baeker T.R., Rothstein T.L. Effects of anti-IgM on mitogen-induced proliferation of human B-lymphocyte malignancies Clinical Immunology and Immunopathology. 1986;39(2):285-297.
Rothstein T. Stimulation of B cells by sequential addition of anti-immunoglobulin antibody and cytochalasin Journal of Immunology. 1986;136(3):813-816.
Rothstein T. Stimulation of normal but not xid-defective B cells by calcium ionophore and cytochalasin Journal of Immunology. 1986;136(3):749-751.
Rothstein T.L., Baeker T.R., Miller R.A., Kolber D.L. Stimulation of murine B cells by the combination of calcium ionophore plus phorbol ester Cellular Immunology. 1986;102(2):364-373.
Rothstein T.L., Kolber D.L., Simons E.R., Baeker T.R. Inhibition by phorbol esters of antiimmunoglobulin induced calcium signalling and B‐cell activation Journal of Cellular Physiology. 1986;129(3):347-355.
Baeker T.R., Rothstein T.L. Proliferation of human malignant lymphocytes induced by anti-IgM independent of B cell growth factor Journal of Immunology. 1985;134(5):3532-3538.
Rothstein T.L. Anti-immunoglobulin in combination with cytochalasin stimulates proliferation of murine B lymphocytes Journal of Immunology. 1985;135(1):106-110.
Weissman D., Parker D.J., Rothstein T.L., Marshak-Rothstein A. Methods for the production of xenogeneic monoclonal antibodies in murine ascites Journal of Immunology. 1985;135(2):1001-1003.
Weissman D., Rothstein T., Marshak-Rothstein A. Growing xenogenic monoclonals in murine ascites Federation Proceedings. 1985;44(4)
Weissman D., Rothstein T.L., Marshak-Rothstein A. A rapid method for comparing monoclonal antibodies by limited proteolysis and electrophoresis Hybridoma. 1985;4(4):329-339.
Rothstein T.L., Miller R.A., Parker D.J., Kelly E., Paul Vastola A., Marshak-Rothstein A. Induction of idiotope suppression in the anti-azophenylarsonate response of T-depleted A/J mice Journal of Experimental Medicine. 1984;159(4):1283-1288.
Rothstein T.L., Vastola A.P. Homologous monoclonal antibodies induce idiotope-specific suppression in neonates through maternal influence and in adults exposed during fetal and neonatal life Journal of Immunology. 1984;133(3):1151-1154.
MARGOLIES M.N., JUSZCZAK E.C., NEAR R., MARSHAK‐ROTHSTEIN A., ROTHSTEIN T.L., SATO V.L., SIEKEVITZ M., SMITH J.A., WYSOCKI L.J., GEFTER M.L. Structural Correlates of Idiotypy in the Arsonate System Annals of the New York Academy of Sciences. 1983;418(1):48-64.
Rothstein T.L., Gefter M.L. Affinity analysis of idiotype-positive and idiotype-negative Ars-binding hybridoma proteins and Ars-immune sera Molecular Immunology. 1983;20(2):161-168.
Rothstein T.L., Margolies M.N., Gefter M.L., Marshak-Rothstein A. Fine specificity of idiotope suppression in the a/j anti-azophenylarsonate response Journal of Experimental Medicine. 1983;157(2):795-800.
Mond J., Mage M., Rothstein T., Mosier D., Herrod H., Asofsky R., Paul W. High anti-TNP plaque-forming cell potential of residual mIg <sup>+</sup> cells in a T cell population Journal of Immunology. 1980;125(4):1526-1529.
Rothstein T., Mage M., Mond J., McHugh L. Guinea pig antiserum to mouse cytotoxic T lymphocytes and their precursors Journal of Immunology. 1978;120(1):209-215.
Rothstein T.L., Mage M., Jones G., McHugh L.L. Cytotoxic T lymphocyte sequential killing of immobilized allogeneic tumor target cells measured by time-lapse microcinematography Journal of Immunology. 1978;121(5):1652-1656.
Mage M., McHugh L., Rothstein T. Mouse lymphocytes with and without surface immunoglobulin: Preparative scale separation in polystyrene tissue culture dishes coated with specifically purified anti-immunoglobulin Journal of Immunological Methods. 1977;15(1):47-56.
Mage M., McHugh L., Rothstein T. Separation of graft versus host antigen reactive cells in vitro Transplantation Proceedings. 1976;8(3):399-401.
Blum J., Rothstein T. Lysosomes in Tetrahymena. Frontiers of biology. 1975;43(4):33-45.
ROTHSTEIN T., BLUM J. Lysosomal Physiology in Tetrahymena. II. Effect of Culture Age and Temperature on the Extracellular Release of 3 Acid Hydrolases The Journal of Protozoology. 1974;21(1):163-168.
Rothstein T., Blum J. Lysosomal physiology in Tetrahymena. IV. Effect of dichloroisoproterenol on the intracellular source of released acid hydrolases Experimental Cell Research. 1974;87(1):168-174.
Rothstein T., Blum J. Lysosomal physiology in tetrahym en A: III. pharmacological studies on acid hydrolase release and the ingestion and egestion of dimethylbenzanthracene particles Journal of Cell Biology. 1974;62(3):844-859.
Rothstein T., Blum J. Lysosomal physiology in tetrahymena: I. effect of glucose, acetate, pyruvate, and carmine on intracellular content and extracellular release of three acid hydrolases Journal of Cell Biology. 1973;57(3):630-641.
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Presentations
- FAIM Prevents Aggregation of Pathogenic Tau Protein Associated with Alzheimer's Disease. Balaj A, Rothstein T, Kaku H, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- Altered Amyloid Beta 42 Aggregation in a Cerebrospinal Fluid Mimetic. Gutknecht M, Rothstein T, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- Human B1 Cells and Natural Antibodies in Health and Disease. Rothstein T, Michael K Bach Distinguished Visiting Lecturer in Immunology at Western Michigan University, Kalamazoo, Michigan, 04/2023
- A Novel Microparticle Immunocapture Assay to Measure Proteostatic Activity. Edmond D, Mohamadi K, Gutknecht M, Rothstein T, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Small heat shock proteins synergize with FAIM to prevent the characteristic amyloid-β aggregation of Alzheimer's disease. Balaj A, Rothstein T, Kaku H, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Immunoglobulin M is Packaged into B Cell-Derived Extracellular Vesicles and Can Be Transferred to Secondary Cells. Gutknecht M, Holodick N, Rothstein T, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Influence of age, sex, and environment on the diversity of the murine gut microbiome and expression of pro-inflammatory cytokines. Webster S, Vos D, Rothstein T, Holodick N, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Characterization of Immunoglobulin M in B-Cell-Derived Extracellular Vesicles. Gutknecht M, Holodick N, Rothstein T, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- Development and Functional Characterization of Anti-Phosphorylcholine Antibodies Against Streptococcus Pneumoniae. Khan N, Ludlow A, Guo X, Brightwell A, Rothstein T, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021