Nichol E Holodick, PhD
Associate Professor, Department of Investigative Medicine
Biosketch
Dr. Holodick performed her undergraduate work at Northeastern University in Boston, Massachusetts. She obtained her PhD in Immunology from Boston University in 2009, working on signaling and development of B-1 cells. Dr. Holodick expanded her work on B-1 cells during a postdoctoral fellowship at the Feinstein Institute for Medical Research in Manhasset, New York. During this time, she focused her research on the role of B-1 cells in infection during aging. Recently, Dr. Holodick was appointed to Assistant Professor in the Center for Immunobiology and Department of Biomedical Sciences at Western Michigan University School of Medicine. She currently studies the role of B-1 cells in protection from pneumococcal infection in sickle cell disease and B-1 cell development in young and aged mice.
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- PhD 2009, Immunology, Boston University
- BS 2003, Biology, Northeastern University
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- Age-Related Changes in Antigen-Specific Natural Antibodies Are Influenced by Sex. Webster SE, Tsuji N, Clemente MJ, Holodick NE, Gordon Research Conference: Sex Differences in Immunity, Ventura, California, 04/2923
- Loss of estrogen signaling alters B-1 cells in a model of polycystic ovarian syndrome. Vergara R, Webster S, Hurley I, Holodick N, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
- Analysis of the B-1 cell repertoire post-Pneumovax23 vaccination in a mouse model of sickle cell disease. Les SM, Tsuji NL, Holodick NE, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
- Impact of TLR stimulation on the CD5+ and CD5- B-1 cell repertoires with age. Helmich M, Webster S, Tsuji N, Holodick N, 42nd Annual Kalamazoo Community and Health Sciences Research Day, Kalamazoo, Michigan, 04/2024
- B Cell-Derived Natural IgM Maintains Retinal Homeostasis throughout Lifespan. Les SM, Webster SE, Heck DM, Jones P, Clemente MJ, Holodick NE, 41st Annual Kalamazoo Community Medical & Health Sciences Research Day, Kalamazoo, Michigan, 05/2023
- Age-Related Changes in Antigen-Specific Natural Antibodies Are Influenced by Sex. Holodick N, Department of Microbiology Seminar at Miami University, Oxford, Ohio, 04/2023
- Age-Related Changes in Antigen-Specific Natural Antibodies Are Influenced by Sex. Holodick N, Gordon Research Conference: Sex Differences in Immunity, Ventura, California, 04/2023
- Under Pressure: Genetic and Sex-Based Influences on Natural Antibodies and Natural Antibody Producing Cells. Webster SE, Vergara R, Tsuji N, Heck D, Clemente MJ, Holodick NE, Gordon Research Conference: Sex Differences in Immunity, Ventura, California, 04/2023
- Age-Related Changes in Antigen-Specific Natural Antibodies Are Influenced by Sex. Holodick N, Department of Biological Sciences Seminar at Western Michigan University, Kalamazoo, Michigan, 04/2023
- Influence of age, sex, and environment on the diversity of the murine gut microbiome and expression of pro-inflammatory cytokines. Webster S, Vos D, Rothstein T, Holodick N, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Immunoglobulin M is Packaged into B Cell-Derived Extracellular Vesicles and Can Be Transferred to Secondary Cells. Gutknecht M, Holodick N, Rothstein T, 40th Annual Kalamazoo Community Medical and Health Sciences Research Day, Kalamazoo, Michigan, 04/2022
- Characterization of Immunoglobulin M in B-Cell-Derived Extracellular Vesicles. Gutknecht M, Holodick N, Rothstein T, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- Differential Gene Expression in Aged B Cells: A Role for Sex. Ryali B, Holodick N, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- The Role of IgM in Selection of the Murine B-1A Cell Repertoire with Increasing Age. Ewing P, Tsuji N, Holodick N, 38th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2021
- Analysis of B cell progenitors in sickle cell disease. Chou J, Holodick N, 36th Annual Kalamazoo Community Medical and Health Sciences Virtual Research Day, Kalamazoo, Michigan, 04/2019