Sunil Nagpal, MD

Hanlon M.M., Smith C.M., Canavan M., Neto N.G.B., Song Q., Lewis M.J., O'rourke A.M., Tynan O., Barker B.E., Gallagher P., Mullan R., Hurson C., Moran B., Monaghan M.G., Pitzalis C., Fletcher J.M., Nagpal S., Veale D.J., Fearon U. Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset Science Advances. 2024;10

Hanlon M.M., Mcgarry T., Marzaioli V., Amaechi S., Song Q., Nagpal S., Veale D.J., Fearon U. Rheumatoid arthritis macrophages are primed for inflammation and display bioenergetic and functional alterations Rheumatology United Kingdom. 2023;62:2611-2620.

Lowe K., Small A., Song Q., Hao L.Y., Murray-Brown W., Proudman S., Smith M.D., Nagpal S., Wechalekar M.D. Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment Scientific Reports. 2023;13

Floudas A., Smith C.M., Tynan O., Neto N., Krishna V., Wade S.M., Hanlon M., Cunningham C., Marzaioli V., Canavan M., Fletcher J.M., Mullan R.H., Cole S., Hao L.Y., Monaghan M.G., Nagpal S., Veale D.J., Fearon U. Distinct stromal and immune cell interactions shape the pathogenesis of rheumatoid and psoriatic arthritis Annals of the Rheumatic Diseases. 2022;81:1224-1242.

Loza M.J., Nagpal S., Cole S., Laird R.M., Alcala A., Rao N.L., Riddle M.S., Porter C.K. Serologic Biomarkers of Progression Toward Diagnosis of Rheumatoid Arthritis in Active Component Military Personnel Arthritis and Rheumatology. 2022;74:1766-1775.

Murray-Brown W., Guo Y., Small A., Lowe K., Weedon H., Smith M.D., Lester S.E., Proudman S.M., Rao N.L., Hao L.Y., Nagpal S., Wechalekar M.D. Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium Rmd Open. 2022;8

Small A., Cole S., Wang J.J., Nagpal S., Hao L.Y., Wechalekar M.D. Attenuation of the BTLA/HVEM Regulatory Network in the Circulation in Primary Sjögren’s Syndrome Journal of Clinical Medicine. 2022;11

Canavan M., Marzaioli V., Bhargava V., Nagpal S., Gallagher P., Hurson C., Mullan R., Veale D.J., Fearon U. Functionally Mature CD1c+ Dendritic Cells Preferentially Accumulate in the Inflammatory Arthritis Synovium Frontiers in Immunology. 2021;12

Floudas A., Canavan M., McGarry T., Mullan R., Nagpal S., Veale D.J., Fearon U. Acpa status correlates with differential immune profile in patients with rheumatoid arthritis Cells. 2021;10:1-15.

Krishna V., Yin X., Song Q., Walsh A., Pocalyko D., Bachman K., Anderson I., Madakamutil L., Nagpal S. Integration of the transcriptome and genome-wide landscape of BRD2 and BRD4 binding motifs identifies key superenhancer genes and reveals the mechanism of bet inhibitor action in rheumatoid arthritis synovial fibroblasts Journal of Immunology. 2021;206:422-431.

McGarry T., Hanlon M.M., Marzaioli V., Cunningham C.C., Krishna V., Murray K., Hurson C., Gallagher P., Nagpal S., Veale D.J., Fearon U. Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease Clinical and Translational Immunology. 2021;10

Canavan M., Marzaioli V., McGarry T., Bhargava V., Nagpal S., Veale D.J., Fearon U. Rheumatoid arthritis synovial microenvironment induces metabolic and functional adaptations in dendritic cells Clinical and Experimental Immunology. 2020;202:226-238.

Floudas A., Neto N., Marzaioli V., Murray K., Moran B., Monaghan M.G., Low C., Mullan R.H., Rao N., Krishna V., Nagpal S., Veale D.J., Fearon U. Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint Jci Insight. 2020;5

Porter C.K., Riddle M.S., Laird R.M., Loza M., Cole S., Gariepy C., Alcala A., Gutierréz R., Baribaud F., Rao N.L., Nagpal S. Cohort profile of a US military population for evaluating pre-disease and disease serological biomarkers in rheumatoid and reactive arthritis: Rationale, organization, design, and baseline characteristics Contemporary Clinical Trials Communications. 2020;17

Zhang H., Lapointe B.T., Anthony N., Azevedo R., Cals J., Correll C.C., Daniels M., Deshmukh S., Van Eenenaam H., Ferguson H., Hegde L.G., Karstens W.J., Maclean J., Miller J.R., Moy L.Y., Simov V., Nagpal S., Oubrie A., Palte R.L., Parthasarathy G., Sciammetta N., Van Der Stelt M., Woodhouse J.D., Trotter B.W., Barr K. Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases ACS Medicinal Chemistry Letters. 2020;11:114-119.

Ai R., Laragione T., Hammaker D., Boyle D.L., Wildberg A., Maeshima K., Palescandolo E., Krishna V., Pocalyko D., Whitaker J.W., Bai Y., Nagpal S., Bachman K.E., Ainsworth R.I., Wang M., Ding B., Gulko P.S., Wang W., Firestein G.S. Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes Nature Communications. 2018;9

Canavan M., Walsh A.M., Bhargava V., Wade S.M., McGarry T., Marzaioli V., Moran B., Biniecka M., Convery H., Wade S., Orr C., Mullan R., Fletcher J.M., Nagpal S., Veale D.J., Fearon U. Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis Jci Insight. 2018;3

Cole S., Walsh A., Yin X., Wechalekar M.D., Smith M.D., Proudman S.M., Veale D.J., Fearon U., Pitzalis C., Humby F., Bombardieri M., Axel A., Adams H., Chiu C., Sharp M., Alvarez J., Anderson I., Madakamutil L., Nagpal S., Guo Y. Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus Arthritis Research and Therapy. 2018;20

Dunleavy K., Fanale M.A., Abramson J.S., Noy A., Caimi P.F., Pittaluga S., Parekh S., Lacasce A., Hayslip J.W., Jagadeesh D., Nagpal S., Lechowicz M.J., Gaur R., Lucas A., Melani C., Roschewski M., Steinberg S.M., Jaffe E.S., Kahl B., Friedberg J.W., Little R.F., Bartlett N.L., Wilson W.H. Dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) in untreated aggressive diffuse large B-cell lymphoma with MYC rearrangement: a prospective, multicentre, single-arm phase 2 study Lancet Haematology. 2018;5(12):e609-e617.

Guo Y., Walsh A.M., Canavan M., Wechalekar M.D., Cole S., Yin X., Scott B., Loza M., Orr C., McGarry T., Bombardieri M., Humby F., Proudman S.M., Pitzalis C., Smith M.D., Friedman J.R., Anderson I., Madakamutil L., Veale D.J., Fearon U., Nagpal S. Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression Plos One. 2018;13

Tilvawala R., Nguyen S.H., Maurais A.J., Nemmara V.V., Nagar M., Salinger A.J., Nagpal S., Weerapana E., Thompson P.R. The Rheumatoid Arthritis-Associated Citrullinome Cell Chemical Biology. 2018;25:691-704.e6.

Guo Y., Walsh A.M., Fearon U., Smith M.D., Wechalekar M.D., Yin X., Cole S., Orr C., McGarry T., Canavan M., Kelly S., Lin T.A., Liu X., Proudman S.M., Veale D.J., Pitzalis C., Nagpal S. CD40L-dependent pathway is active at various stages of rheumatoid arthritis disease progression Journal of Immunology. 2017;198:4490-4501.

Unwalla R., Mousseau J.J., Fadeyi O.O., Choi C., Parris K., Hu B., Kenney T., Chippari S., McNally C., Vishwanathan K., Kilbourne E., Thompson C., Nagpal S., Wrobel J., Yudt M., Morris C.A., Powell D., Gilbert A.M., Chekler E.L.P. Structure-Based Approach to Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators Journal of Medicinal Chemistry. 2017;60:6451-6457.

Walsh A.M., Wechalekar M.D., Guo Y., Yin X., Weedon H., Proudman S.M., Smith M.D., Nagpal S. Triple DMARD treatment in early rheumatoid arthritis modulates synovial T cell activation and plasmablast/plasma cell differentiation pathways Plos One. 2017;12

Scheepstra M., Leysen S., Van Almen G.C., Miller J.R., Piesvaux J., Kutilek V., Van Eenennaam H., Zhang H., Barr K., Nagpal S., Soisson S.M., Kornienko M., Wiley K., Elsen N., Sharma S., Correll C.C., Trotter B.W., Van Der Stelt M., Oubrie A., Ottmann C., Parthasarathy G., Brunsveld L. Identification of an allosteric binding site for RORγt inhibition Nature Communications. 2015;6

Chekler E.L.P., Unwalla R., Khan T.A., Tangirala R.S., Johnson M., St. Andre M., Anderson J.T., Kenney T., Chiparri S., McNally C., Kilbourne E., Thompson C., Nagpal S., Weber G., Schelling S., Owens J., Morris C.A., Powell D., Verhoest P.R., Gilbert A.M. 1-(2-hydroxy-2-methyl-3-phenoxypropanoyl)indoline-4-carbonitrile derivatives as potent and tissue selective androgen receptor modulators Journal of Medicinal Chemistry. 2014;57:2462-2471.

Chaigne-Delalande B., Li F.Y., O'Connor G.M., Lukacs M.J., Jiang P., Zheng L., Shatzer A., Biancalana M., Pittaluga S., Matthews H.F., Jancel T.J., Bleesing J.J., Marsh R.A., Kuijpers T.W., Nichols K.E., Lucas C.L., Nagpal S., Mehmet H., Su H.C., Cohen J.I., Uzel G., Lenardo M.J. Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D Science. 2013;341:186-191.

Kilbourne E.J., Kenney T., Chippari S., McNally C., Wang Y., Lam H.S., Vishwanathan K., Nagpal S., Thompson C.C., Piatnitski Chekler E.L. Probing androgen receptor co-factor selectivity profiles: A chemical tool to determine cross-talk between androgen receptor and β-catenin in vivo Medchemcomm. 2013;4:582-589.

Hargrove J.B., Bennett R.M., Simons D.G., Smith S.J., Nagpal S., Deering D.E. A randomized placebo-controlled study of noninvasive cortical electrostimulation in the treatment of fibromyalgia patients Pain Medicine. 2012;13:115-124.

Na S., Ma Y., Zhao J., Schmidt C., Zeng Q.Q., Chandrasekhar S., Chin W.W., Nagpal S. A nonsecosteroidal vitamin D receptor modulator ameliorates experimental autoimmune encephalomyelitis without causing hypercalcemia Autoimmune Diseases. 2011;1

Shen Q., Bai Y., Chang K.C.N., Wang Y., Burris T.P., Freedman L.P., Thompson C.C., Nagpal S. Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes Journal of Biological Chemistry. 2011;286:14554-14563.

Sirop S., Kanaan M., Korant A., Wiese D., Eilender D., Nagpal S., Arora M., Singh T., Saha S. Detection and prognostic impact of micrometastasis in colorectal cancer Journal of Surgical Oncology. 2011;103(6):534-537.

Yudt M.R., Russo L.A., Berrodin T.J., Jelinsky S.A., Ellis D., Cohen J.C., Cooch N., Haglund E., Unwalla R.J., Fensome A., Wrobel J., Zhang Z., Nagpal S., Winneker R.C. Discovery of a novel mechanism of steroid receptor antagonism: WAY-255348 modulates progesterone receptor cellular localization and promoter interactions Biochemical Pharmacology. 2011;82:1709-1719.

Berrodin T.J., Shen Q., Quinet E.M., Yudt M.R., Freedman L.P., Nagpal S. Identification of 5α,6α-epoxycholesterol as a novel modulator of liver X receptor activity Molecular Pharmacology. 2010;78:1046-1058.

Chang K., Wang Y., Bodine P., Nagpal S., Komm B. Gene expression profiling studies of three SERMs and their conjugated estrogen combinations in human breast cancer cells: Insights into the unique antagonistic effects of bazedoxifene on conjugated estrogens Journal of Steroid Biochemistry and Molecular Biology. 2010;118:117-124.

Chang K.C.N., Wang Y., Oh I.G., Jenkins S., Freedman L.P., Thompson C.C., Chung J.H., Nagpal S. Estrogen receptor β is a novel therapeutic target for photoaging Molecular Pharmacology. 2010;77:744-750.

Crabtree J.S., Kilbourne E.J., Peano B.J., Chippari S., Kenney T., McNally C., Wang W., Harris H.A., Winneker R.C., Nagpal S., Thompson C.C. A mouse model of androgenetic alopecia Endocrinology. 2010;151:2373-2380.

Hargrove J.B., Bennett R.M., Simons D.G., Smith S.J., Nagpal S., Deering D.E. Quantitative electroencephalographic abnormalities in fibromyalgia patients Clinical EEG and Neuroscience. 2010;41:132-139.

Li N., Rivéra-Bermúdez M.A., Zhang M., Tejada J., Glasson S.S., Collins-Racie L.A., LaVallie E.R., Wang Y., Chang K.C.N., Nagpal S., Morris E.A., Flannery C.R., Yang Z. LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model Proceedings of the National Academy of Sciences of the United States of America. 2010;107:3734-3739.

Wyce A., Bai Y., Nagpal S., Thompson C.C. Research resource: The androgen receptor modulates expression of genes with critical roles in muscle development and function Molecular Endocrinology. 2010;24:1665-1674.

Berrodin T., Jelinsky S., Graciani N., Butera J., Zhang Z., Nagpal S., Winneker R., Yudt M. Novel progesterone receptor modulators with gene selective and context-dependent partial agonism Biochemical Pharmacology. 2009;77:204-215.

Berrodin T.J., Chang K.C.N., Komm B.S., Freedman L.P., Nagpal S. Differential biochemical and cellular actions of premarin estrogens: Distinct pharmacology of bazedoxifene-conjugated estrogens combination Molecular Endocrinology. 2009;23:74-85.

Collins-Racie L.A., Yang Z., Arai M., Li N., Majumdar M.K., Nagpal S., Mounts W.M., Dorner A.J., Morris E., LaVallie E.R. Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage. Reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis Osteoarthritis and Cartilage. 2009;17:832-842.

Koury E., Pawlyk A., Berrodin T., Smolenski C., Nagpal S., Deecher D. Characterization of ligands for thyroid receptor subtypes and their interactions with co-regulators Steroids. 2009;74:270-276.

Patel K.J., Nagpal S., Berger K.L., Conley B.A. A clustering of breast, lung, and fallopian tube cancers Community Oncology. 2009;6(4):176-178.

Chang K.C.N., Shen Q., Inn G.O., Jelinsky S.A., Jenkins S.F., Wang W., Wang Y., LaCava M., Yudt M.R., Thompson C.C., Freedman L.P., Jin H.C., Nagpal S. Liver X receptor is a therapeutic target for photoaging and chronological skin aging Molecular Endocrinology. 2008;22:2407-2419.

Cheskis B.J., Greger J., Cooch N., McNally C., Mclarney S., Lam H.S., Rutledge S., Mekonnen B., Hauze D., Nagpal S., Freedman L.P. MNAR plays an important role in ERa activation of Src/MAPK and PI3K/Akt signaling pathways Steroids. 2008;73:901-905.

Dimitrov N.V., Nagpal S., Chitneni S. Management of male breast cancer Oncology Reviews. 2008;2(1):44-52.

Stayrook K.R., Rogers P.M., Savkur R.S., Wang Y., Su C., Varga G., Bu X., Wei T., Nagpal S., Liu X.S., Burris T.P. Regulation of human 3α-hydroxysteroid dehydrogenase (AKR1C4) expression by the liver X receptor α Molecular Pharmacology. 2008;73:607-612.

Wang Y., Rogers P.M., Stayrook K.R., Su C., Varga G., Shen Q., Nagpal S., Burris T.P. The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene Molecular Pharmacology. 2008;74:1716-1721.

Cheskis B.J., Greger J.G., Nagpal S., Freedman L.P. Signaling by estrogens Journal of Cellular Physiology. 2007;213:610-617.

Chintalacharuvu S.R., Sandusky G.E., Burris T.P., Burmer G.C., Nagpal S. Liver X receptor is a therapeutic target in collagen-induced arthritis Arthritis and Rheumatism. 2007;56:1365-1367.

Dimitrov N.V., Colucci P., Nagpal S. Some aspects of the endocrine profile and management of hormone-dependent male breast cancer Oncologist. 2007;12(7):798-807.

Kilbourne E.J., Moore W.J., Freedman L.P., Nagpal S. Selective androgen receptor modulators for frailty and osteoporosis Current Opinion in Investigational Drugs. 2007;8:821-829.

Cheskis B.J., Freedman L.P., Nagpal S. Vitamin D receptor ligands for osteoporosis Current Opinion in Investigational Drugs. 2006;7:906-911.

Ma Y., Khalifa B., Yee Y.K., Lu J., Memezawa A., Savkur R.S., Yamamoto Y., Chintalacharuvu S.R., Yamaoka K., Stayrook K.R., Bramlett K.S., Zeng Q.Q., Chandrasekhar S., Yu X.P., Linebarger J.H., Iturria S.J., Burris T.P., Kato S., Chin W.W., Nagpal S. Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators Journal of Clinical Investigation. 2006;116:892-904.

Lu J., Goldstein K.M., Chen R., Huang S., Gelbert L.M., Nagpal S. Transcriptional profiling of keratinocytes reveals a vitamin D-regulated epidermal differentiation network Journal of Investigative Dermatology. 2005;124:778-785.

Nagpal S. Editorial Mini Reviews in Medicinal Chemistry. 2005;5:699-700.

Nagpal S., Na S., Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands Endocrine Reviews. 2005;26:662-687.

Savkur R., Bramlett K., Stayrook K., Nagpal S., Burris T. Coactivation of the human vitamin D receptor by the peroxisome proliferator-activated receptor γ coactivator-1 α Molecular Pharmacology. 2005;68:511-517.

Yee Y.K., Chintalacharuvu S.R., Lu J., Nagpal S. Vitamin D receptor modulators for inflammation and cancer Mini Reviews in Medicinal Chemistry. 2005;5:761-778.

Bettoun D.J., Lu J., Khalifa B., Yee Y., Chin W.W., Nagpal S. Ligand modulates VDR-Ser/Thr protein phosphatase interaction and p70S6 kinase phosphorylation in a cell-context-dependent manner Journal of Steroid Biochemistry and Molecular Biology. 2004;89-90:195-198.

Nagpal S. Retinoids: Inducers of tumor/growth suppressors Journal of Investigative Dermatology. 2004;123:xx-xxi.

Bettoun D.J., Burris T.P., Houck K.A., Buck D.W., Stayrook K.R., Khalifa B., Lu J., Chin W.W., Nagpal S. Retinoid X Receptor Is a Nonsilent Major Contributor to Vitamin D Receptor-Mediated Transcriptional Activation Molecular Endocrinology. 2003;17:2320-2328.

Nagpal S. An orphan meets family members in skin Journal of Investigative Dermatology. 2003;120:viii-x.

Pinette K.V., Yee Y.K., Amegadzie B.Y., Nagpal S. Vitamin D receptor as a drug discovery target. Mini Reviews in Medicinal Chemistry. 2003;3:193-204.

Bettoun D.J., Buck D.W., Lu J., Khalifa B., Chin W.W., Nagpal S. A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand Journal of Biological Chemistry. 2002;277:24847-24850.

Nagpal S., Ghosn C.R., Chandraratna R.A. Identification of nuclear receptor interacting proteins using yeast two-hybrid technology. Applications to drug discovery. Methods in Molecular Biology Clifton N J. 2001;176:359-376.

Nagpal S., Lu J., Boehm M. Vitamin D analogs: Mechanism of action and therapeutic applications Current Medicinal Chemistry. 2001;8:1661-1679.

Thacher S., Vasudevan J., Tsang K., Nagpal S., Chandraratna R. New dermatological agents for the treatment of psoriasis Journal of Medicinal Chemistry. 2001;44:281-297.

Wakino S., Kintscher U., Kim S., Jackson S., Yin F., Nagpal S., Chandraratna R.A.S., Hsueh W.A., Law R.E. Retinoids inhibit proliferation of human coronary smooth muscle cells by modulating cell cycle regulators Arteriosclerosis Thrombosis and Vascular Biology. 2001;21:746-751.

Deucher A., Nagpal S., Chandraratna R.A., Di Sepio D., Robinson N.A., Dashti S.R., Eckert R.L. The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity. International Journal of Oncology. 2000;17:1195-1203.

Duvic M., Helekar B., Schulz C., Cho M., DiSepio D., Hager C., DiMao D., Hazarika P., Jackson B., Breuer-McHam J., Young J., Clayman G., Lippman S.M., Chandraratna R.A.S., Robinson N.A., Deucher A., Eckert R.L., Nagpal S. Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer Clinical Cancer Research. 2000;6:3249-3259.

Kintscher U., Goetze S., Wakino S., Kim S., Nagpal S., Chandraratna R.A.S., Graf K., Fleck E., Hsueh W.A., Law R.E. Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes European Journal of Pharmacology. 2000;401:259-270.

Masood R., Nagpal S., Zheng T., Cai J., Tulpule A., Smith D.L., Gill P.S. Kaposi sarcoma is a therapeutic target for vitamin D3 receptor agonist Blood. 2000;96:3188-3194.

Nagpal S., Chandraratna R. Recent developments in receptor-selective retinoids Current Pharmaceutical Design. 2000;6:919-931.

DiSepio D., Chandraratna R., Nagpal S. Novel approaches for the treatment of psoriasis Drug Discovery Today. 1999;4:222-231.

DiSepio D., Sutter M., Johnson A., Chandraratna R., Nagpal S. Identification of the AP1-Antagonism domain of retinoic acid receptors Molecular Cell Biology Research Communications. 1999;1:7-13.

Nagpal S., Ghosn C., DiSepio D., Molina Y., Sutter M., Klein E.S., Chandraratna R.A.S. Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor Journal of Biological Chemistry. 1999;274:22563-22568.

Thacher S.M., Nagpal S., Klein E.S., Arefieg T., Krasinski G., DiSepio D., Agarwal C., Johnson A., Eckert R.L., Chandraratna R.A.S. Cell type and gene-specific activity of the retinoid inverse agonist AGN 193109: Divergent effects from agonist at retinoic acid receptor γ in human keratinocytes Cell Growth and Differentiation. 1999;10:255-262.

Disepio D., Ghosn C., Eckert R.L., Deucher A., Robinson N., Duvic M., Chandraratna R.A.S., Nagpal S. Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene Proceedings of the National Academy of Sciences of the United States of America. 1998;95:14811-14815.

Melle-Milovanovic D., Milovanovic M., Nagpal S., Sachs G., Shin J.M. Regions of association between the alpha and the subunit of the gastric H,K ATPase FASEB Journal. 1998;12:A1019.

Melle-Milovanovic D., Milovanovic M., Nagpal S., Sachs G., Shin J.M. Regions of association between the α and the β subunit of the gastric H,K-ATPase Journal of Biological Chemistry. 1998;273:11075-11081.

Nagpal S., Chandraratna R. Future directions in retinoid therapy Dermatologic Therapy. 1998;7:58-62.

Nagpal S., Chandraratna R. Vitamin a and regulation of gene expression Current Opinion in Clinical Nutrition and Metabolic Care. 1998;1:341-346.

Boehm M.F., Heyman R.A., Nagpal S. A new generation of retinoid drugs for the treatment of dermatological diseases Emerging Drugs. 1997;2:287-304.

DiSepio D., Malhotra M., Chandraratna R.A.S., Nagpal S. Retinoic acid receptor-nuclear factor-interleukin 6 antagonism. A novel mechanism of retinoid-dependent inhibition of a keratinocyte hyperproliferative differentiation marker Journal of Biological Chemistry. 1997;272:25555-25559.

Duvic M., Nagpal S., Asano A.T., Chandraratna R.A.S. Molecular mechanisms of tazarotene action in psoriasis Journal of the American Academy of Dermatology. 1997;37:S18-S24.

Nagpal S., Cai J., Zheng T., Patel S., Masood R., Lin G.Y., Priant S., Johnson A., Smith D.L., Chandraratna R.A.S., Gill P.S. Retinoid antagonism of NF-IL6: Insight into the mechanism of antiproliferative effects of retinoids in Kaposi's sarcoma Molecular and Cellular Biology. 1997;17:4159-4168.

Nagpal S., Chandraratna R. Chapter 20. New Dermatological Agents for the Treatment of Psoriasis Annual Reports in Medicinal Chemistry. 1997;32:201-210.

Nagpal S., Patel S., Jacobe H., DiSepio D., Ghosn C., Malhotra M., Teng M., Duvic M., Chandraratna R.A.S. Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin Journal of Investigative Dermatology. 1997;109:91-95.

Agarwal C., Chandraratna R.A.S., Teng M., Nagpal S., Rorke E.A., Eckert R.L. Differential regulation of human ectocervical epithelial cell line proliferation and differentiation by retinoid X receptor-and retinoic acid receptor-specific retinoids Cell Growth and Differentiation. 1996;7:521-530.

Klein E.S., Pino M.E., Johnson A.T., Davies P.J.A., Nagpal S., Thacher S.M., Krasinski G., Chandraratna R.A.S. Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists Journal of Biological Chemistry. 1996;271:22692-22696.

Nagpal S., Chandraratna R.A.S. Retinoids as Anti-Cancer Agents Current Pharmaceutical Design. 1996;2:295-316.

Nagpal S., Patel S., Asano A.T., Johnson A.T., Duvic M., Chandraratna R.A.S. Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin Journal of Investigative Dermatology. 1996;106:269-274.

Nagpal S., Thacher S.M., Patel S., Friant S., Malhotra M., Shafer J., Krasinski G., Asano A.T., Teng M., Duvic M., Chandraratna R.A.S. Negative regulation of two hyperproliferative keratinocyte differentiation markers by a retinoic acid receptor-specific retinoid: Insight into the mechanism of retinoid action in psoriasis Cell Growth and Differentiation. 1996;7:1783-1791.

Boehm M.F., Heyman R.A., Patel S., Stein R.B., Nagpal S. Section review: Retinoids: Biological function and use in the treatment of dermatological diseases: Pulmonary-allergy, dermatological, gastrointestinal & arthritis Expert Opinion on Investigational Drugs. 1995;4:593-612.

Chandraratna R.A.S., Henry E., Attard J., Gillett S.J., Song T., Garst M.E., Nagpal S., Athanikar J., Arefieg T., Gil D.W., Wheeler L.A., Lew-Kaya D., Sefton J. Development of RAR subtype selective retinoids for dermatological diseases European Journal of Medicinal Chemistry. 1995;30

Nagpal S., Athanikar J., Chandraratna R.A.S. Separation of transactivation and AP1 antagonism functions of retinoic acid receptor α Journal of Biological Chemistry. 1995;270:923-927.

Nagpal S., Ostrove J. Erratum: Characterization of a potent varicella-zoster virus-encoded trans-repressor (Journal of Virology 65:10 (5289-5296)) Journal of Virology. 1995;69:2723.

LEID M., KASTNER P., DURAND B., KRUST A., LEROY P., LYONS R., MENDELSOHN C., NAGPAL S., NAKSHATRI H., REIBEL C., SAUNDERS M., CHAMBON P. Retinoic Acid Signal Transduction Pathways Annals of the New York Academy of Sciences. 1993;684:19-34.

Nagpal S., Friant S., Nakshatri H., Chambon P. RARs and RXRs: Evidence for two autonomous transactivation functions (AF-1 and AF-2) and heterodimerization in vivo EMBO Journal. 1993;12:2349-2360.

Shanti K.N., Martin B.M., Nagpal S., Metcalfe D.D., Rao P. Identification of tropomyosin as the major shrimp allergen and characterization of its IgE-binding epitopes Journal of Immunology. 1993;151(10):5354-5363.

Nagpal S., Saunders M., Kastner P., Durand B., Nakshatri H., Chambon P. Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors Cell. 1992;70:1007-1019.

Nagpal S., Zelent A., Chambon P. RAR-β4, a retinoic acid receptor isoform is generated from RAR-β2 by alternative splicing and usage of a CUG initiator codon Proceedings of the National Academy of Sciences of the United States of America. 1992;89:2718-2722.

Namboodiri M.S.A., Nagpal S., Subba Rao P.V. Induction of anti-DNA IgG and IgE antibodies in BALB c mice Journal of Autoimmunity. 1992;5(5):653-663.

Nagpal S., Namboodiri M.S.A., Rao B., Rao P.V.S. IgG4 autoantibodies to DNA in systemic lupus erythematosus patients International Archives of Allergy and Immunology. 1991;95(1):1-6.

Nagpal S., Ostrove J.M. Characterization of a potent varicella-zoster virus-encoded trans-repressor Journal of Virology. 1991;65:5289-5296.

SRIRAMARAO P., NAGPAL S., SUBBA RAO B., PRAKASH O., SUBBA RAO P. Immediate hypersensitivity to Parthenium hysterophorus. II. Clinical studies on the prevalence of parthenium rhinitis Clinical Experimental Allergy. 1991;21(1):55-62.

Nagpal S., Sriramarao P., Krishnaswamy P., Metcalfe D., Rao P. Demonstration of ige antibodies to nucleic acid antigens in patients with sle Autoimmunity. 1990;8(1):59-64.

Nicholson R.C., Mader S., Nagpal S., Leid M., Rochette-Egly C., Chambon P. Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site EMBO Journal. 1990;9:4443-4454.

Shetty N., Nagpal S., Rao P.V., Schroder H. Detection of IgG, IgA, IgM and IgE in antibodies in invasive amoebiasis in endemic areas. Archivos De Investigacion Medica. 1990;21 Suppl 1:41-46.

Shetty N., Nagpal S., Subba Rao P.V., Schröder H. Detection of igg, iga, igm and ige antibodies in invasive amoebiasis in endemic areas Scandinavian Journal of Infectious Diseases. 1990;22(4):485-491.

Inchauspe G., Nagpal S., Ostrove J. Mapping of two varicella-zoster virus-encoded genes that activate the expression of viral early and late genes Virology. 1989;173:700-709.

Nagpal S., Rajappa L., Metcalfe D., Subba Rao P. Isolation and characterization of heat-stable allergens from shrimp (Penaeus indicus) Journal of Allergy and Clinical Immunology. 1989;83(1):26-36.

Nagpal S., Shanthi K.N., Kori R., Schroder H., Metcalfe D.D., Rao P.V.S. Induction of allergen-specific IgE and IgG responses by anti-idiotypic antibodies Journal of Immunology. 1989;142(10):3411-3415.

Nagpal S., Metcalfe D., Subba Rao P. Identification of a shrimp-derived allergen as tRNA Journal of Immunology. 1987;138(12):4169-4174.